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Step 1 Immunology-First Aid 2017 > Hypersensitivity types > Flashcards

Hypersensitivity types Flashcards

1
Q

Mast cells and basophils releasing cytokines that induce cellular inflammation is seen in…

A

Delayed phase of Type I hypersensitivity reaction

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2
Q

Type I hypersensitivity reaction immediate phase involves…

A

immediate release of vasoactive amines at postcapillary venules

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3
Q

Reaction of type I hypersensitivity reaction occurs rapidly because of…

A

preformed antibodies

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4
Q

Anaphylatic and atopic reaction is what type of hypersensitivity reaction

A

Type I

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5
Q

What antibody cross-links on presensitized mast cells and basophils

A

IgE

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6
Q

IgE cross-linking on presensitized mast cells and basophils triggers…

A

immediate release of histamine at postcapillary venules

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7
Q

Food, drug, or bee stings causing anaphylaxis are examples of…

A

Type I hypersensitivity reaction

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8
Q

Skin test or blood test like ELISA for allergen-specific IgE illicits what hypersensitivity reaction?

A

Type I

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9
Q

Test that detects antibodies attached to RBC surface

A

Direct Coombs test

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10
Q

Test that detects presence of unbound antibodies in serum

A

Indirect Coombs test

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11
Q

Direct and Indirect Coombs test are what type of hypersensitivity reaction

A

Type II

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12
Q

Antibodies that bind to cell-surface antigens causing cellular destruction, inflammation, and dysfunction is what type of hypersensitivity reaction?

A

Type II

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13
Q

Phagocytosis and/or activation of complement causing cellular destruction is what type of hypersensitivity reaction?

A

Type II

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14
Q

Antibody-dependent cellular cytotoxicity is what type of hypersensitivity reaction

A

Type II

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15
Q

Autoimmune hemolytic anemia is what type of hypersensitivity reaction

A

Type II

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16
Q

Immune thrombocytopenic purpura is what type of hypersensitivity reaction

A

Type II

17
Q

Transfusion reactions are what type of hypersensitivity reaction

A

Type II

18
Q

Hemolytic disease of the newborn is what type of hypersensitivity reaction

A

Type II

19
Q

Binding of antibodies to cell surfaces causing activation of complement system and Fc receptor-mediated inflammation is what type of hypersensitivity reaction

A

Type II

20
Q

Goodpasture syndrome, Rheumatic fever, and hyperacute transplant rejection are what type of hypersensitivity reactions

A

Type II

21
Q

Antibodies binding to cell surface receptros causing abnormal blockade or activation of downstream process is what type of hypersensitivity reaction

A

Type II

22
Q

Myesthenia gravis, Graves disease, and pemphigous vulgaris are what type of hypersensitivity reactions

A

Type II

23
Q

Antigen-antibody-complement immune complex is what type of hypersensitivity reaction

A

Type III

24
Q

SLE, Polyarteritis nodosa, Poststreptococcal glomerulonephritis are what type of hypersensitivity reactions

A

Type III

25
Q

Type III hypersensitivity reactions involve what type of cells?

A

Antigen-antibody-complement complex that attracts neutrophils that release lysosomal enzymes

26
Q

Arthus reaction are caused by what?

A

Antigen-antibody complexes

27
Q

Immune complex disease in which antibodies to foreign proteins are produced and can take 5-10 days

A

Serum sickness

28
Q

Fever, urticaria, arthralgia, proteinuria, lymphadenopathy after antigen exposure is seen in what?

A

Serum sickness, a type III hypersensitivity reaction

29
Q

Edema, necrosis, and activation of complement after an intradermal injection causing and immune-complex formation is seen in what?

A

Arthus reaction, at type III hypersensitivity reaction

30
Q

Immune complexes deposit in membranes that fix complement is seen in what?

A

Serum sickness, a type III hypersensitivity reaction

31
Q

Type IV hypersensitivity reaction involving direct cell cytotoxicity involves what cell types?

A

CD8+ cytotoxic T-cells

32
Q

Delayed-type IV hypersensitivity reaction involves what cell types?

A

CD4+ helper T-cells

33
Q

Mechanism of macrophage activation in delayed-type IV hypersensitivity reaction

A

CD4+ helper T-cells encounter antigen, release cytokines causing inflammation and macrophage activation

34
Q

Hypersensitivity reaction that does not involve antibodies

A

Type IV

35
Q

Which hypersensitivy reactions involve antibodies

A

Type I, II, III

36
Q

Diabetes mellitus type I is what type of hypersensitivy reaction

A

Type IV, direct cell cytotoxicity

37
Q

Contact dermatitis like poisin ivy or nickel allergy is what type of hypersensitivy reaction

A

Type IV, delayed

38
Q

Graft-vs-host disease is what type of hypersensitivy reaction

A

Type IV, delayed

Step 1 Immunology-First Aid 2017 (30 decks)

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