Differentiation of T cells Flashcards
Area of T-cell positive selection
Thymic cortex
Area of T-cell negative selection
Thymic medulla
T-cells expressing TCRs capable of binding self-MHC on cortical epithelial cells occurs where?
Thymic cortex
Type of selection when T-cells express TCRs capable of binding self-MHC on cortical epithelial cells
Positive selection
T-cells expressing TCRs with high affinity for self antigens undergo apoptosis occurs where
Thymic medulla
Type of selection when T-cells express TCRS with high affinity for self antigen undergo apoptosis
Negative selection
Fas-FasL interaction of T-cells occurs where?
Thymic medulla
Mutations in Fas cause what?
Increase in circulating self-reacting lymphocytes due to failure of clonal deletion of T-cells
Autoimmune lymphoproliferative syndrome is caused by what?
Defective Fas-FasL binding
Why is Fas-Fasl interaction necessary?
Fas-FasL binding in negative selection induces apoptosis of T-cells that bind self-antigen too avidly within the thymic medulla
T-cell that differentiates into Cytotoxic T-cells
CD8+ T-cell
T-cell that differentiates into Helper T-cells
CD4+ T-cell
