Spleen

Question 1

a. total platelet in the spleen
b. total platelet in the circulation

Answer 1

a. 1/3 (30%)
b. 2/3

Question 2

Lymphoid tissue that contains lymphocytes, macrophages and dendritic cells

Answer 2

white pulp

Question 3

a. where T cell reside
b. where B cell reside
c. where activated B cell reside

Answer 3

a. PALS
b. primary follicles
c. secondary follicles/ germinal center

Question 4

It contains specialized macrophages for removal of the senescent RBCs

Answer 4

Red pulp

Question 5

a. Removal of mature or senescent RBC through phagocytosis
b. Removal of RBC inclusions (bite cells)

Answer 5

a. Culling
b. Pitting

Question 6

Absence of splenic function caused by either surgical removal or radiation exposure

Answer 6

Asplenia / Splenectomy

Question 7

a. hypersplenism/ splenomegaly
b. asplenia/ splenectomy
c. autosplenectomy

Answer 7

a. pancytopenia
b. pancocytosis
c. necrosis of spleen due to sickle cell anemia

Question 8

Commonly used markers
a. CD 4
b. CD 8
c. CD 34
d. CD 16, 56, 94
e. CD 13, 33
f. CD 2, 3
g. CD 9, 20

Answer 8

a. helper/ inducer T cells
b. supressor/ cytotoxic T cells
c. hematopoietic stem cell marker
d. NK cells
e. pan myeloid cells
f. lymphoid pan T cells
g. lymphoid pan B cells

Question 9

Cytokines with stem cell mobilization

Answer 9

G-CSF
GM-CSF
IL-3

Question 10

Primary cell source of EPO

Answer 10

kidney

Question 11

primary target cell is T cell

Answer 11

IL-2
IL-6
IL- 10
IL- 12