Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MICRO 442 > SPIROCHETES!!! MICROM 442 Deck 14 > Flashcards

SPIROCHETES!!! MICROM 442 Deck 14 Flashcards

1
Q

B.hermsii disease=

A

relapsing fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

B. burgdoferi disease =

A

Lyme disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T. pallidum disease =

A

syphilis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

L. interrogans disease =

A

leptospirosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

structure is distinctively

A

corkscrew shaped with Lipid-rich outer membrane covering periplasmic
flagella; thin peptidoglycan layer covering
cytoplasmic membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is special about the leptospira shape?

A

has hooked ends

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

B. hermsii + B. burgdorferi have what type of chromosome structure

A

linear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

all expect one has high genetic variability?

A

T. pallidum/syphillis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which two do not have confirmed plasmids (the other 2 have both circular and linear)?

A

syphillis and leptospirosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

all have a small genome size except?

A

L. interrogans which makes sense because she is able to infect people although we are accidental hosts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

One circular chromosome in

A

T. pallidum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Two circular chromosomes in

A

Leptospira

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Syphilis manifestations

A
  • Chronic bacterial infection, sexually transmitted
  • Early manifestations involve primarily skin
  • Late manifestations involve virtually all organs
    and tissue sites, including the central nervous
    system
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Syphilis habitat

A

Human only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Syphilis: Transmission

A
  • Direct, usually sexual, contact with infectious
    person (1⁰ or 2⁰ stage)
  • Organism is highly invasive; gains access to blood
    stream and disseminates throughout body,
    including central nervous system
  • May also cross placenta to cause congenital
    syphilis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Congenital Syphilis

A
  • Infection of fetus during
    pregnancy
  • Results in prematurity,
    spontaneous abortion,
    stillbirth, neonatal illness
    or death, latent infection
17
Q

Syphilis: Pathogenesis

A
  • Immune response ultimately clears primary
    and secondary lesions, but infection is not
    eradicated systemically
  • Causes lifelong persistent, chronic infection
    in untreated persons
  • Antigenic variation if pivotal to persistence
18
Q

Antigenic Variation of TprK

A
  • Surface-exposed protein
  • Has 7 variable regions
  • Antigenic variation by
    segmental gene conversion
    o One expression site
    o 53 variable region donor
    sites
    Accounts for development of SECONDARY stage,
    lifetime persistence
19
Q

Syphilis: Treatment

A
  • Penicillin –first line
  • Alternatives: doxycycline, tetracycline, amoxicillin
  • Macrolides – high rates of resistance in circulating strains – no
    longer recommended
20
Q

Syphilis: Lab Diagnosis

A

– PCR, RT-PCR not commercially available
– Darkfield microscopy
– No culture technique available (in vitro
cultivation system is not yet adapted)

21
Q

relapsing fever passed on by two arthopods which are?

A

louse-bourne and tick-borne

22
Q

Tick borne (B. hermsii) relapsing fever

A

Humans infected via tick saliva (or feces) during tick bite—
only short feeding is required for transmission

23
Q

Louse borne (B. recurrentis) relapsing fever

A

‒ No invasion of louse tissue (stay in the hemolymph). No
transovarial transmission
‒ Humans are infected by hemolymph/feces when parasite is
crushed (mechanical transmission only)

24
Q

ultimately relapsing fever has a decreasing burden but reinfections because of the

A

different serotypes and the the antibodies having to compensate

25
Q

Relapsing Fever has which genes for antigenic variation?

A

vlp and vsp

26
Q

Lyme Disease surface proteins

A

OspA, OspB, OspC

27
Q

lyme disease major resevoir=

A

small rodents mostly but also birds and deer and TRANSMITTED via TICK bite

28
Q

Lyme Disease: Pathogenesis

A
  • Organism is very invasive, reaches blood
    stream and disseminates to many organs,
    including central nervous system
  • Persistent, chronic infection (due to antigenic
    variation of surface antigens?)
29
Q

Lyme Disease: Clinical Course

A

1: Erythema chronicum migrans (ECM)
and secondary lesions
2: Neurologic and cardiac abnormalities:
headache, stiff neck, conjunctivitis,
muscle pain, (weeks to months
after ECM)
3: Arthritis (weeks to years after ECM) -
intermittent or chronic

30
Q

Lyme Disease: Treatment

A

Penicillin, ceftriaxone, tetracyclines
* Later treatment may not be successful:
chronic inflammation in absence of bacteria
(Autoimmunity, chronic inflammation due to
PG fragments?)

31
Q

Leptospirosis: Habitat

A
  • Most widespread zoonosis in the world
  • Free-living in water
  • Animal reservoir–domestic and wild animals
32
Q

Leptospirosis: Transmission

A
  • Source of infection is water contaminated with the
    infected urine of “carrier” animals
  • Portal of entry is skin, mucous membranes
  • Carrier state persists for months to years
33
Q

Leptospirosis: Pathogenesis

A
  • Invasive
  • Disseminates to infect multiple organs,
    including central nervous system
34
Q

Clinical Outcomes of Leptospiral Infection

A

inapparent infx -> undifferentiated fever -> Complex, multi-system disease (Aseptic meningitis
Renal failure
Jaundice
Myocarditis
Pulmonary hemorrhage
Refractory shock)

35
Q

Leptospirosis: Clinical Course

A
  • Sudden onset of fever (spiking), severe
    myalgia, headache
  • Bacteria present in blood, CSF, urine
  • Usually self-limited, but can be protracted and severe

MICRO 442 (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions