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MICRO 442 > Chlamydia!!! MICROM 442 Deck 13 > Flashcards

Chlamydia!!! MICROM 442 Deck 13 Flashcards

1
Q

Elementary body (EB)

A

-infectious
-EXC spore-like form
-Metabolically inert, non-replicating

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2
Q

Reticulate body (RB)

A

-Non-infectious
-Intracellular replicating form
-Divide within membrane-bound inclusion
-Osmotically unstable, can’t survive extracellularly

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3
Q

Genome for family chlamydiaceae

A

Small chromosome

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4
Q

what type of organism is chlyamdia??

A

obligate & intracellular

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5
Q

what does it secrete?

A

type III secreted effectors, which both EBs and RBs express

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6
Q

EBs induce epithelial cell internalization

A

¤ Pre-formed effector protein, Tarp, secreted into target cell
¤ Tarp induces actin polymerization, phagocytosis of EB

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7
Q

RBs secrete Inc proteins: modify the inclusion membrane

A

Prevent lysosome fusion by blocking SNARE-mediated interactions

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8
Q

C. trachomatis infects mucosal epithelial cells

A

¤ Secretory antibodies are produced but are not associated with
disease resolution
¤ Infection controlled by T H 1 (interferon-g-associated) immune response
¤ Provokes a low level chronic inflammatory response
¤ Necrosis, epithelial cell proliferation, and scar tissue formation
¤ Scarring responsible for most disease-associated complications

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9
Q

C. trachomatis servoars A-C =

A

trachoma

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10
Q

C. trachomatis servoars D-K =

A

¤ Urethritis/Cervicitis
¤ Perinatal infections
¤ Inclusion conjunctivitis

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11
Q

C. trachomatic L1, L2, L3=

A

Lymphogranuloma venereum (LGV)

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12
Q

LGV serovars specically invade the

A

lymph nodes where they survive/replicate in phagocytes

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13
Q

A-K serovars are taken up and killed by

A

phagocytes & invade immune cells

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14
Q

CT infx in men -> urethritis

A

Dysuria with some urethral discharge
¤ Commonly less purulent (pus-inducing) than
gonorrhea
¤ More likely to be asymptomatic than gonorrhea
¤ Epididymitis is common complication
¤ Frequently unilateral, not associated with infertility

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15
Q

CT infx in women

A

¤ Dysuria, frequency
¤ Absence of WBC in the urine (in contrast to E. coli UTI)

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16
Q

e.coli vs CT UTI

A

no WBCs in urine when CT

17
Q

CT cervicitis

A

¤ Most infected women are asymptomatic
¤ Mucopurulent cervical discharge
¤ Friability (easily induced bleeding)
¤ Untreated infections persist for months

18
Q

Chlamydia trachomatis:
Urogenital infections

A

¤ Pelvic inflammatory disease (PID)
¤ Endometritis (uterine lining)
¤ Salpingitis (fallopian tubes)
¤ Peritonitis (peritoneal cavity)
¤ Symptoms range from none to acute and severe
¤ Discharge, bleeding, fever, abdominal tenderness and pain
¤ Symptomatic PID occurs in ~10-15% of women with endocervical C.
trachomatis infections

19
Q

CT neonatal infx

A

inclusion conjunctivitis & pneumonia

20
Q

CT Dx

A

-NAAT
-screening

21
Q

CT stages

A

1° -> Small ulcer on genital mucosa or
adjacent skin & Few or no symptoms, rapidly heals
2° -> Inguinal lymphadenopathy, fever,
headache, muscle pain
3° -> Chronic procto-colitis mimics inflammatory
bowel diseases

22
Q

CT A-C pathogenesis

A

Chronic follicular conjunctivitis -> Ulceration and scarring of cornea, loss of vision

23
Q

trachoma is most active in

A

infected children who are a resevoir -> transmission from nasopharyngeal secretions via hands/flies/objects

24
Q

chlamydia pneumoniae

A

C. pneumoniae infects and multiplies within a wide range of cell types,
including monocytes/macrophages

25
Q

C. Pneumonia spread via

A

respiratory droplets and clinically indistinguishable from other causes of pneumonia

26
Q

chlaymdophila psittaci

A

acquired from birds via inhalation

27
Q

chlaymdophila psittaci prevention

A

Quarantine and treatment of imported birds

28
Q

chlaymdophila psittaci dx

A

Severity ranges from mild febrile disease to fatal
pneumonia
¤ 20% fatality in untreated disease

29
Q

vax for chlamydia?

A

NO

30
Q

abx must be able to

A

penetrate tissues and enter host cells

MICRO 442 (25 decks)

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