SPIROCHETES Flashcards
SPIROCHETES motility
corkscrew
Organisms that can’t be visualize in brightfield microscopy
SPIROCHETES
SPIROCHETES are Motile because they produce
axial fibrils (flagella)
disease of blood vessels; sexually transmitted disease
Syphilis
turning threads
Treponema
Non-culturable on artificial media
Treponema pallidum
Treponema pallidum treatment
Penicillin - Jarisch-Herxheimer reaction
transplacental transmission of syphilis
Congenital Syphillis
Congenital Syphilis
○ Early stage is like the second stage or _______
○ Late stage is the latent stage or _______
condylomata
deadly
seen in children who had congenital syphilis (3)
Hutchinson triad
■ deafness
■ blindness
■ notched or pegged teeth
Clinical Infection of Syphilis
Primary Stage. (4)
Hard Chancre
- unitarian?
- genitalia dry lesions
- not painful
Clinical Infection of Syphilis
Secondary Stage (5)
Condylomata lata
- wart-like
- genitalia
- 6-8 weeks
- after dry lesions (hard chancre)
Clinical Infection of Syphilis
Latent Stage (3)
Asymptomatic
- hidden
- serological stage
Clinical Infection of Syphilis
Tertiary Stage (3)
Gumma’s
- deep organs
- neuro/cardiac syphilis
Syphilis Serological Tests
Non-Treponemal
Treponemal
sero test that is not specific for syphilis
Non-Treponemal
specific test for syphilis
Treponema
Non-Treponemal tests (3)
● VDRL
● RPR
● TRUST
Treponemal tests (5)
● TPI
● TPHA
● MHA-TP
● FTA-ABS
● RPCF
heated serum (waterbath); microscopic
VDRL
RPR (4)
commonly used today;
neurosyphilis (CSF);
modified version of VDRL;
macroscopic
most specific test for syphilis
FTA-ABS
uses nonvirulent treponeme; nonreactive for late stage of syphilis
RPCF
Yaw or Frambesia
T. pallidum subsp. pertenue
Bejel
T. pallidum subsp. endemicum
Carate or Pinta
T. pallidum subsp. carateum
endemic syphilis
T. pallidum subsp. endemicum
oldest human treponema
T. pallidum subsp. carateum
● Transmitted thru flies
● crab feet/yaws
● Disease of bone, skin and joints
T. pallidum subsp. pertenue
