Special Topics (Skin)

Question 1

1

Answer 1

Stratum basale
Keratinocytes stem cells
Transmit amplifying ones proliferate

Question 2

2

Answer 2

Stratum spinosum
Keratinocytes start to flatten.
Keratin, int.f. and desmosome junctions.
8-10 layers

Question 3

3

Answer 3

Stratum granulosum
Keratinocytes die.
Lamellar granules fuse to PM and release lipid rich secretions to help form barrier.
Keratohyalin - dark granules which help form keratin int. Filaments into keratin.

Question 4

4

Answer 4

Stratum lucidum

Only thick skin.

Question 5

5

Answer 5

Stratum corneum
Flattened, dead keratinocytes.
25-30 layers.

Question 6

How often does stratification occur?

Answer 6

Once a month.

Question 7

Where are melanocytes found?

Answer 7

BM on epidermal side.

Question 8

What do melanocytes do?

Answer 8

Make melanosomes (which contain melanin) which are transferred to keratinocytes. Dendrites extend out to help transfer.

Question 9

What are the 2 types of melanin?

Answer 9

Pheomelanin- yellow red

Eumelanin- brown black

Question 10

What do Langerhans do?

Answer 10

Immune

Survey epidermis for foreign organisms then move them to the dermis to be destroyed.

Question 11

What 4 things is the BM made of?

Answer 11

Collagen, perlecan, nidogen, laminin

Question 12

What does epidermolysis bullosa cause?

Answer 12

Mutations in BM proteins

Question 13

Name the 4 phases of healing

Answer 13

Inflammatory, migratory, proliferative, maturation

Question 14

Name the 5 functions of skin

Answer 14

Barrier, holds blood, thermoregulation, sensation, vitamin D (modified by UV, made in liver)