Somatostatin analogues Flashcards
1
Q
What are examples of somatostatin analogues?
A
- Ocreotide
- Lancreotide
2
Q
What are indications for somatostatin analogues?
A
- Acromegaly
- Carcinoid Syndrome
- Thyroid Tumours
3
Q
When would you want to be cautious when using somatostatin analogues?
A
- Diabetes
- Insulinoma
- Pregnancy
4
Q
What is the mechanism of action of somatostatin analogues?
A
Inhibits growth hormone and IGF-1, along with a range of other effects on the GI tract. It is therefore treatment of choice in acromegaly and a range of endocrine tumours
5
Q
What are adverse reactions of somatostatin analogues?
A
- GI upset
- Steatorrhoea
- Impaired glucose tolerance
- Gallstones
- Irritation at injection sites
- Pancreatitis (rare)
