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PHO > Solid Tumors > Flashcards

Solid Tumors Flashcards

1
Q

t(11;22)

A

EWSR1-FLI1

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2
Q

t(21;22)

A

EWSR1-ERG

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3
Q

t(4;19) or t(10;19)

A

CIC-DUX4

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4
Q

inv(X)(p11)

A

BCOR-CCNB3

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5
Q

t(11;22)

A

EWSR1-WT1

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6
Q

Rothmund-Thomson syndrome gene

A

RECQL4

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7
Q

OS locations

A

distal femur, prox tibia, prox humerus, pelvic

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8
Q

EWS locations

A

femur, ileum, tib/fib and then chest wall/rib

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9
Q

congenital fibrosarcoma fusion

A

ETV6-NTRK3 = t(12;15)

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10
Q

desmoplastic round cell tumor fusion

A

EWSR1-WT1 = t(11;22)

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11
Q

rhabdoid tumor fusion

A

22q11.2 inactivation = INI1 loss (or SMARCB1)

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12
Q

malignant peripheral nerve sheath tumor association

A

NF1

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13
Q

lower risk RMS

A

orbit, GU non-bladder/non-prostate

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14
Q

higher risk RMS

A

extremity, some parameningeal

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15
Q

only STS not treated with surgery

A

desmoid tumor

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16
Q

only STS with autoSCT

A

DSRCT

17
Q

only STS where surgery may not be needed

A

congenital fibrosarcoma (very chemo-sensitive)

18
Q

WT1 location and association

A

ch11p13; WAGR (deletion), Denys-Drash (missense)

19
Q

WT2 location and association

A

ch11p15; Beckwith-Wiedemann syndrome (hypermethylation)

20
Q

anaplastic Wilms association

A

TP53 mutations (Li-Fraumeni)

21
Q

RCC tx

A

surgery with LN dissection

22
Q

tRCC special characteristic

A

TFE3 or TFEb nuclear expression

23
Q

renal medullary carcinoma genetics

A

sickle cell trait; INI-1 loss

24
Q

clear cell sarcoma of the kidney molecular finding

A

BCOR ITDs

25
Q

malignant rhabdoid tumor loss

A

INI-1 (germline or somatic)

26
Q

congenital mesoblastic nephroma cellular fusion/gene

A

t(12;15) = ETV6-NTRK3

27
Q

cystic nephroma association

A

DICER mutations

28
Q

Flank XRT for Wilms

A

1080 cGy

29
Q

Lung XRT for Wilms

A

1200 cGy

30
Q

Fibrolamellar HCC

A

DNAJB1-PRKACA fusion

31
Q

Low AFP, lung Mets, < 1yo

A

Small cell undifferentiated hepatoblastoma (SMARCB1)

32
Q

Low AFP, lung Mets, AYA

A

Fibrolamellar HCC (DNAJB1-PRKACA fusion)

PHO (15 decks)

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