Lymphoma

Question 1

LP cell - feature and association

Answer 1

“popcorn” from convoluted irregular nuclei; NLPHD

Question 2

cHL IHC

Answer 2

CD15+ CD30+ CD45-

Question 3

NLPHL IHC

Answer 3

CD15- CD30- CD45+

Question 4

Ann Arbor stage 1

Answer 4

single node region or single extra-lymphatic organ/site

Question 5

Ann Arbor stage 2

Answer 5

two or more node regions on the same side of the diaphragm

Question 6

Ann Arbor stage 3

Answer 6

nodes on both sides of the diaphragm

Question 7

Ann Arbor stage 4

Answer 7

diffuse/disseminated involvement

Question 8

Bulk definition (X)

Answer 8

Mediastinal mass > 1/3 thoracic diameter, nodal aggregate > 6cm and macroscopic splenic nodules

Question 9

Burkitt IHC

Answer 9

CD10, 19, 20, 22, sIg+

Question 10

DLBCL IHC

Answer 10

sIg+, CD19, 20, 22, 79a and PAX-5

Question 11

Primary mediastinal B cell lymphoma genetics

Answer 11

9p24.1 amplification (increased PD-L1/2 expression)

Question 12

Anaplastic large cell lymphoma IHC

Answer 12

CD15- CD30+ CD45+

Question 13

Anaplastic genetics

Answer 13

t(2;5) - NPM-ALK fusion