ALL

Question 1

Infant ALL genetics

Answer 1

KMT2A-R

Question 2

Common genetic abnormality in DS-ALL

Answer 2

CRLF2

Question 3

Hypereosinophilia ALL translocation

Answer 3

t(5;14) - IgH

Question 4

Hypereosinophilia blast detection

Answer 4

IgH FISH

Question 5

Hypercalcemia translocation

Answer 5

t(17;19)

Question 6

t(17;19) -> gene

Answer 6

TCF3::HLF fusion -> translocation

Question 7

t(12;21) -> gene

Answer 7

ETV6::RUNX1 -> translocation

Question 8

t(1;19) -> gene

Answer 8

TCF3::PBX1 -> translocation

Question 9

t(v;11) or t(11;v) -> gene

Answer 9

KMT2A rearrangements

Question 10

t(9;22) -> gene

Answer 10

BCR::ABL1 -> translocation

Question 11

iAMP21

Answer 11

Poor prognosis with SR ALL therapy

Question 12

focal del Xp22/Yp11

Answer 12

P2RY8::CRLF2 (DS-ALL)

Question 13

Ph-like ALL alterations

Answer 13

del-IKZF1, CRLF2 rearrangements, JAK1/2 mutations

Question 14

Steinherz/Bleyer equation

Answer 14

If (CNS WBC/CNS RBC) > 2x(serum WBC/serum RBC), then it is CNS disease

Question 15

CNS dx ppx XRT

Answer 15

1200 cGy

Question 16

CNS dx tx XRT

Answer 16

1800 cGy and includes the posterior globes of the eyes

Question 17

Inotuzumab

Answer 17

CD22-calicheamicin

Question 18

Blinatumomab

Answer 18

CD3-CD19+ BiTE

Question 19

t(11;14) gene

Answer 19

TCRA-LMO2 (T-ALL)

Question 20

t(Y;14) gene

Answer 20

IgH-CRLF2, seen in Ph-like ALL and Hispanic adolescents

Question 21

Testicular relapse XRT dose

Answer 21

2400 cGy bilaterally (give systemic chemo too)