AML/CML Flashcards by Perry Morocco | Brainscape

Q

Big 4 of AML

A

t(8;21), inv(16), t(15;17), abnormal 11q23

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Q

t(8;21) -> gene

A

AML1-ETO or RUNX1-RUNX1T1 -> translocation

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Q

inv(16) -> gene

A

CBFB-MYH11 -> translocation

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Q

t(15;17) -> gene

A

PML-RARA -> translocation

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Q

abnormal 11q23 -> gene

A

MLL-partner -> translocation

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Q

DBA gene

A

RPS19, RPL5 -> disorder

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Q

t-AML from topo II + latency

A

11q23, latency 1-2yrs

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Q

t-AML from alkylators/radiation + latency

A

-5, -7, del(5q), del(7q), latency 5-7

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Q

AMKL mutation

A

GATA1 with DS

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Q

AMKL immunophenotype

A

CD42+, CD61+, absent MPO

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Q

“RAM” immunophenotype

A

bright CD56, dim/neg CD45, dim/neg CD 38 and neg HLA-DR

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Q

Gemtuzumab ozogamicin target

A

CD33

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Q

HR APL

A

WBC > 10K (add idarubicin)

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Q

CML blast percentage for chronic phase

A

<10% in bone marrow or serum

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Q

CML blast percentage for accelerated phase

A

10-19% in the bone marrow or serum

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