SNS - Organic Chemistry - DAT Destroyer Flashcards
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Corey House Reaction
This is a good synthetic way to join two alkyl groups together.
R2CuLi + R’-X ⇔ R-R’ + R-Cu + LiX
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OsO4 reacts with alkenes to 1,2-diols
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Heat caused free radical formation
Free radical addition occurs at least substituted carrbon (bound to least other carbons) - anti-Markovnikov
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Wolff Kishner
Reduction carbonyls to alkanes
NH2NH2 for hydrazone formation
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Normally Grignard reagents don't react with ethers, but ethylene is a strained epoxide and will react
Epoxide ring is opened by Grignards and protonated to yield primary alcohol
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Grignard
Leaving group either a halide or an alkoxide - in this case, a halide (Br)
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Formation of Grignard Reagents
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Esters can only be reduced by LiAlH4 NOT by the less reactive NaBH4
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Condensation with an ammonia derivative
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KCN = nucleophile
Aromatic rings readily undergo electrophilic but not nucleophilic substitution
Therefore no reaction
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Organometallic compounds react with water (moisture).
It is a convenient way to reduce an alkyl halide to an alkane. (R-X →R-H)
The use of Grignards and deuterium oxide (D2O) is a useful way to
incorporate Deuterium into an organic molecule. (R-X → R-D)
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