SNRIs Flashcards
1
Q
Seretonin-Norepinephrine Reuptake Inhibitors
A
Therapeutic class: Antidepressant; Anxiolytic
Examples:
duloxetine (Cymbalta) and venlafaxine (Effexor)
2
Q
Mechanisms of action
A
Inhibits reuptake of serotonin and norepinephrine, elevating mood, ma affect dopamine levels
3
Q
Actions and Uses
A
Safer than other classes
Less common sympathomimetic effect ( increased HR and HTN)
Can cause weight gain and sexual dysfunction
4
Q
Adverse Effects
A
Abnormal dreams Sweating Constipation Dry mouth Loss of appetite Weight loss Tremor Abnormal vision Headache N/V Dizziness Loss of sexual desire
5
Q
Contraindications
A
With seizures; bupropion (Wellbutrin)
Use with caution in underlying CV cases
6
Q
Black Box Warning
A
Risk for suicidal actions
7
Q
Interactions
A
bupropion and levodopa increases adverse effects
platelet aggregation may be impaired
