Antipsychotic

Question 1

Therapeutic Class

Answer 1

benzisoxazole

Question 2

Examples

Answer 2

risperidone (Risperdal), olanzapine (Zyprexa), quetiapine (Seroquel), ziprasidone (Geodon)

Question 3

Mechanism of Action

Answer 3

Selective monaminergic antagonist with strong affinity for serotonin receptors and weaker affinity for dopamine
Antipsychotic activity may be mediated through antagonism at combination of receptor sites

Question 4

Actions and Uses

Answer 4

Bipolar 1 disorder, Schizophrenia

Question 5

Adverse Effects

Answer 5

Rash, hyperproactinemia, weight gain, constipation, diarrhea, excessive salivation, increased appetite, indigestion, nausea, vomiting, dizziness, dystonia, Parkinsonism, tremor, prolonged QT interval, DKA, hypothermia, pancreatitis, agranulocytosis, priapism, neuroleptic malignant syndrome

Question 6

Black Box Warning

Answer 6

Dementia-related psychosis: increased risk of death

Question 7

Contraindications

Answer 7

Paliperidone (active metabolite of risperidone)

Question 8

Interactions

Answer 8

ketoconzole, citalopram, -floxacins, linezolid, methadone, many more

Question 9

Pregnancy Category

Answer 9

fetal risk cannot be ruled out