NDRIs

Question 1

Norepinephrine/dopamine reuptake inhibitor

Answer 1

Therapeutic class: Antidepressant
Examples:
buproprion (Wellbutrin)

Question 2

Mechanism of Action

Answer 2

Structurally similar to amphetamine (mild stimulant)

Weakly acts as a norepinephrine and dopamine reuptake blocker

Question 3

Actions and Uses

Answer 3

Uniquely increased dopamine in “reward area” of brain
Smoking cessation, depression, major depressive disorder
Minimal sexual dysfunction side effect
Does not inhibit monoamine oxidase or reuptake of serotonin

Question 4

Adverse Effects

Answer 4

Hepatoxicity

If drug abuse history: mild amphetamine-like effect

Question 5

Black Box Warning

Answer 5

Increased risk of suicide

Question 6

Contraindication

Answer 6

Seizure disorder, bulimia/anorexia (increased seizure risk), Zyban (same ingredient), alcohol/drug withdrawal, MAOIs

Question 7

Interactions

Answer 7

Zyban, MAOIs

Question 8

Pregnancy Category

Answer 8

C