Benzodiazepines Flashcards
1
Q
Benzodiazepines
A
Therapeutic class: sedative-hypnotic; anxiolitic Examples: lorazepam (Activan) diazepam ( Valium) alprazolam ( Xanax) clonazepam (Klonopin)
- lorazapam: one of the most potent benzodiazepines
2
Q
Mechanism of Action
A
binds to GABA receptor-chloride channel molecule, which intensifies GABA effects.
3
Q
Actions and Uses
A
Primary use for anxiety disorders and insomnia
Potentiates effects of GABA (inhibitory neurotransmitter)
in thalamic, hypothalamic and limbic levels of CNS.
4
Q
Adverse Effects
A
drowsiness dizziness respiratory depression amnesia ataxia vision changes N/V Assess airway physical dependence
5
Q
Contraindications
A
Acute narrow-angle glaucoma, closed-angle glaucoma, liver disease, impaired brain function, suicidal ideations
6
Q
Interactions
A
May decrease anti-parkinsonism effects of levodopa
Herbals: kava, valerian, chamolmile, hops
7
Q
Overdose
A
flumazenil (Romazicon) reverses CNS depressant effects
8
Q
Pregnancy Category
A
C
