MAOIs

Question 1

Monoamine oxidase inhibitors

Answer 1

Therapeutic class: antidepressant

Question 2

Example

Answer 2

phenelzine (Nardil)
tranylcypromine (Parnate)
isocaboxazid (Marplan)

Question 3

Mechanism of Action

Answer 3

to decrease effectiveness of monoamine oxidase

produces irreversible inhibition of MAO which intensifies effects of norepinephrine

Question 4

Actions and Uses

Answer 4

depression, panic disorder

anxiety (off label)

Question 5

Adverse Effects

Answer 5

orthostatic hypotension
diarrhea
headache
insomnia
abrupt discontinuation may cause rebound hypertension
overdose: seizures, respiratory depression, circulatory collapse, coma

Question 6

Black Box Warning

Answer 6

Increase risk of suicidal thinking, not approved in peds

Question 7

Contraindication

Answer 7

CV or cerebrovascular disease, hepatic/renal impairment, pheochromocytoma

Question 8

Interactions

Answer 8

SSRIs (seretonin syndrome)
Avoid foods containing tyramine (hypertensive crisis)
Caffeine may cause cardiac dysrhythmias and hypertension
Herbal: ginseng (HA), ma huang, ephedra and St. John;s Wort (HTN crisis)

Question 9

Pregnancy Category

Answer 9

C