SARIs/ SSRIs Flashcards
1
Q
What?
A
Serotonin 2 agonist/Serotonin reuptake inhibitor
2
Q
Therapeutic class
A
Antidepressant
3
Q
Examples
A
trazodone (Desyrel), nefazodone (Serzone)
4
Q
Mechanism of Action
A
Not fully understood but does not have similarity to TCAs or MAOIs
5
Q
Actions and Uses
A
Inhibits neuronal reuptake of serotonin and acts as antagonist at 5-ht-2a/2c serotonin receptors
6
Q
Adverse Effects
A
Postural hypotension constipation diarrhea nausea vomiting confusion dizziness headache insomnia blurred vision dream disorder cardiac dysrhythmia prolonged QT interval torsades de pointes seizure priapism
7
Q
Black Box Warning
A
Potential for suicide risk
8
Q
Contraindications
A
MAOIs, saquinavir/ritonavir
9
Q
Interactions
A
MAOIs: serotonin syndrome
10
Q
Pregnancy Category
A
Fetal risk cannot be ruled out
