snake venom Flashcards
difference between venomous and poisonous
venomous by sting or bite,
poisonous by injestion/ absorption
both toxic substances
what is the efffect on coagulation
procoagulant
widespread clotting
anticogulant activity
how do we determine lethality
50% of mice killed 24/48h period (lower= more lethal)
differences between pre-synaptic and post-synaptic neurotoxins
postsynaptic- responds to anticholinesterases and antivenoms
presynaptic only antivenom that is given early
treatment
Struan Sutherland’s pressure and immobilisation
antivenoms - milked from snake farms
monovalent vs polyvalent
monovalent against one venom, polyvalent against many.
challenges in producing antivenoms
need correct venoms
species vary by place
death by snake
paralysis
haemorrhage
renal failure
myotoxins
