skin diseases

Question 1

what type of pathogen causes leprosy

Answer 1

mycobacteria

Question 2

What are the two types of leprosy and what do they act on

Answer 2

lepromatous- TH2 response

Tuberculoid- TH1

Question 3

Symptoms of leprosy

Answer 3

skin lesions and neuronal damage

Question 4

grades of deformity based on where

Answer 4

hands and feet

eyes

Question 5

investigations for leprosy, explain them briefly (2 main)

Answer 5

Slit skin smear - 6 sites smeared for tests, up to 4 other sites with lesions (all cases suspected)
Biopsy and pcr

Question 6

what is done with the skin slit smear

Answer 6

morphology index and bacterial index

tests density and ranks between 1 and 6

Question 7

when do we do skin biopsy

Answer 7

when sss is negative in a suspected case

Question 8

how do we test antibiotic sensitivity

Answer 8

inject into mouse, allow to grow then test (can’t grow in vitro)

Question 9

what is multibacillary leprosy

Answer 9

more than 6 lesions, positive sss

Question 10

types of complication

Answer 10

Type 1: cell mediated hypersensitivity, neural issues, inflammation
Type 2: in thos ewith high bacterial load, systemic issue, oedema in hands/ feet

Question 11

paucibacillary vs multibacillary treatment

Answer 11

multibacillary is similar treatment, just more drugs for longer. surveillance is 15y vs 5y