Dengue Flashcards
population of world affected by dengue
40%
symptoms depend on
viral load and host immune system
seasonal increase after
raining season
vector
mosquitos- aegypti, albopictus
life cycle
mosquito bites infected person mosquito ingests blood and dengue 10-14 day incubation bites person 10-14 days later person gets dengue
dengue structure
single strand rna,
positive sense so directly makes proteins,
genome encodes 10 genes= 10 proteins
what are the 3 structural proteins made by dengue rna
Capsid
Envelope
Membrane
these protect and allow entry to human cells
Which protein is used to detect dengue, what do other nonstructural proteins do
NS1
play role in replication
symptoms of dengue (7)
Fever, headache, hepatomegaly, joint and muscle pain, vomiting rash
warning signs of severe dengue
fluid accumulation
abdo pain
mucosal bleeding
rapid platelet drop
severe dengue
shock ad resp distress due to plasma leakage
severe bleeding
organ involvement: liver, cns, CV
how does dengue activate the T Cells
viral particles from mosquito taken up by APC,
replication in the APC causing apc maturation,
mature apc to lymphatics,
attracts t cells by cytokines
T cells in dengue
secrete pro-inflammatory factors- TNFa INFg (higher= more severe infection) + enzymes and reactive O2 species
glycocalyx in endothelium broken down= leakage of plasma fluid
what is the result of the fluid leakage
increased haemocrit
plural effusions
hypovolemic shock
ascites
who can have the dengue vaccine, why
those previously infected, otherwise vaccine would facilitate severe dengue during an infection from a different stereotype
