Small Molecule Analysis

Question 1

GC/MS systems are widely used for measuring

Answer 1

drugs of abuse in urine toxicology confirmations

Question 2

Drugs and metabolites must be extracted from body fluids and typically reacted with derivatizing reagents to form compounds that are more ______ for the GC process

Answer 2

volatile

Question 3

offers a number of advantages over GC. Typically, LC requires less extensive extraction procedures and derivatization is rarely used, saving time and expense

Answer 3

LC

Question 4

itself in LC can be somewhat less robust than in GC, resulting in wider peaks and more variable retention times and potentially requiring maintenance that is more frequent. Another disadvantage of LC/MS is the less reproducible mass spectra

Answer 4

chromatography

Question 5

For very high volume testing, several HPLC (or UPLC) pumps can be connected to a single mass spectrometer, which is referred to as

Answer 5

multiplexing

Question 6

great potential for measuring low-level and mixed-polarity analytes such as vitamin D, testosterone, and immunosuppressant drugs due to its superior sensitivity and specificity over immunoassays.

Answer 6

LC/MS

Question 7

LC/MS is free from the antibody interferences seen in immunoassays, although LC/MS has its own type of interference in the form of

Answer 7

ion suppression