cc two Flashcards
- Elevation of serum ALP may be seen in:
1) Hepatobiliary disease
2) Growing children
3) Hypoparathyroidism
4) Tumor of the testicle
A. 1 & 2
- The following statements are true of LD:
1) There is elevated serum LD in acute myocardial infarction
2) There is a decrease LD in megaloblastic anemia
3) There are four monomers in the LD isoenzyme structure
4) LD 6 isoenzymes is seen only in muscle disorder
B. 1 & 3
- Amylase is an enzyme useful in the diagnosis of acute pancreatitis, which of the following statements correctly describes Amylase?
1) Amylase is elevated in acute pancreatitis, mumps, parotitis, and perforated peptic ulcer
2) Amylase cleaves glycosidic bonds of polysaccharides
3) It is the largest of all enzymes of molecular weight
4) The p type isoenzyme migrates the fastest, while the s type migrates the slowest
B. 1 & 2
- Which of the following statements is true of the isoenzyme LD 2?
1) It is the slowest moving LD isoenzyme
2) The most positively charged fraction
3) Heat labile fraction
4) It is present in greatest amount in normal tissue
D. 4 only
- Which of the following enzyme is considered as a newborn screening marker?
a. Amylase
b. Aldolase
c. Cholinesterase
d. G6PD
D. G6PD
- A scanning of CK isoenzyme revealed two peaks, a slow cathodic peak (CKMM), and an intermediate peak (CKMB), this is interpreted as?
a. Brain tumor
b. Muscular dystrophy
c. Myocardial infarction
d. Viral hepatitis
C. Myocardial Infarction
- The clinical significance of elevated Acid phosphatase is ____?
a. Renal disease
b. Pancreatic disease
c. Bone disease
d. Prostatic Disease
D. Prostatic Disease
- Test for Acid phosphatase detects levels of enzymes from tissue such as what?
D daw yung sagot di naman sinabi yung choices parang gago, Spleen, Prostate, Platelets, RBC, Liver
- Select the product formed from the forward reaction of AST
a. Alanine & alpha ketoglutarate
b. Aspartate & glutamine
c. Oxaloacetate & glutamate
d. Glutamate & NADH
C. Oxaloacetate & glutamate
- Creatine kinase is frequently elevated in disorders such as AMI and ___
a. Duchenne’s Muscular Dystrophy
b. Acute Hepatitis
c. Cirrhosis
d. Malignancy
A. Duchenne’s Muscular Dystrophy
o CKMM is significantly elevated in muscle disease
- This enzyme is the most specific marker of acute pancreatitis and remains elevated in the blood circulation
a. AST
b. Lipase
c. ALP
d. Amylase
B. Lipase
- This enzyme which affects the cell membrane and microsomal fraction is a sensitive indicator of occult alcoholism
a. ALP
b. AST
c. GGT
d. ALT
C. GGT
- Which two conditions can physiologically elevate serum ALP?
a. Rickets & Hypoparathyroidism
b. Growth & 3rd trimester of pregnancy
c. Obstructive Jaundice & Biliary cirrhosis
d. Viral hepatitis & Infectious mononucleosis
B. Growth & 3rd trimester of pregnancy
- A physician suspects his patient to have pancreatitis, which test would be most indicative of this disease
a. Creatinine
b. LD Isoenzyme
c. Beta hydroxybutyrate
d. Amylase
D. Amylase
- Which of the following chemical determinations may be of help in establishing the presence of seminal fluid?
a. Lactate dehydrogenase
b. Isocitrate dehydrogenase
c. Acid phosphatase
d. Alkaline phosphatase
C. Acid phosphatase
- Increased total serum Lactate dehydrogenase activity confined to fractions 4 and 5 is most likely associated with?
D. Acute viral hepatitis
- Regan isoenzyme has the same properties as alkaline phosphatase that originates in the?
a. Skeleton
b. Kidney
c. Intestine
d. Placenta
D. Placenta
- The most sensitive enzymatic indicator for liver damage from ethanol intake is ?
a. ALT – Acute damage to the liver
b. AST – Chronic progressive damage to the liver
c. GGT
d. ALP – hepatobiliary disease, obstructive jaundice
C. GGT
- A serum sample drawn in the emergency room from a 42-year-old man yielded the following result:
CK: 185 U/L, Normal: 15-160 U/L
AST: 123 U/L, Normal: 0-48 U/L
CKMB: 6 U/L, Normal: 2-12 U/L
a. Crush injury to the thigh
b. Pulmonary infarction
c. Cerebrovascular accident
d. Early acute hepatitis
A. Crush injury to the thigh
- Which of the following enzymes catalyzes the
conversion of starch to glucose and maltose?
a. Malate dehydrogenase
b. Creatine Kinase
c. Amylase
d. Isocitric dehydrogenase
C. Amylase
- Which of the following is a glycolytic enzyme that catalyzes the cleavage of fructose1-6 diphosphate to glyceraldehyde 3-phosphate and dihydroxy-acetone phosphate?
C. Phosphofructokinase
- Which of the following sets of results would be consistent with macroamylasemia
B. Increased serum amylase, normal urine amylase
- Isoenzyme assays are performed to improve ____?
a. Precision
b. Accuracy
c. Sensitivity
d. Specificity
d. Specificity
- What specimen preparation is commonly used to perform the alkaline phosphatase isoenzyme determination?
B. Serum is divided to two aliquots, one is heated at 56OC, the other is not heated
o Heat stability test is used to differentiate Bone ALP (Heat labile) from Liver ALP
- As temperature is increased from 25OC to 37oC in GGT reaction, the activity reaction is ___?
a. Halved
b. Doubled
c. Tripled
d. Reduced to 0
B. Doubled
- One method to enhance the differentiation of Bone from Liver ALP isoenzyme is to pretreat an aliquot of the serum specimen
B. By heating at 56 degC
- Which of the following is associated with organophosphate poisoning?
a. 5’ nucleotidase – hepatobiliary disease and infiltrative lesion of the liver
b. Cholinesterase
c. G6PD – drug induced hemolytic anemia
d. Aldolase – skeletal muscle damage
B. Cholinesterase
- Which of the following may be associated with macro CK?
a. Complex between CKBB and IGG (can also be attached to IGA)
b. Complex between CKMM and IGA (CKMM is attached to lipoprotein)
c. Migrates between CKMM and MB fractions of electrophoresis
d. A and C are both correct
D. A and C are both correct
- In an adult a normal serum GGT level with an elevated serum ALP may be suggestive of ____?
a. Heart disease
b. Bone disease
c. Liver disease
d. Skeletal muscle disease
B. Bone disease
- Which of the following may be associated with CK isoenzyme?
a. CK1 is preferred to as CKMM huh
b. CK3 remains close to the origin during electrophoresis
c. CKMM is found in skeletal muscle
d. Both b and c are correct
D. both b and c are correct
- In pesticide poisoning a decrease in this enzyme activity is associated with?
B. Cholinesterase
o Used as an index to parenchymal activity
- Which of the following is considered as a gold standard test for GH deficiency?
a. Insulin tolerance test
b. Somatomedin C test
c. Arginine tolerance test
d. Urinary growth hormone test
A. Insulin tolerance test
o B, C, D are used for screening
- Composition of TSH except
a. Gamma
b. Delta
c. Alpha
d. None of these
A. Gamma
- It is the regulator of adrenal and androgen synthesis in humans
C. ACTH
- The main stimulus for the uptake of iodide by the thyroid gland is
a. FSH
b. TSH
c. T3
d. T4
B. TSH
- It indirectly mediates metabolic and anabolic functions of GH
a. IGF 1 (Insulin like growth factor 1)
b. Relin
c. Somatomedin C
A and C
- The most abundant of the pituitary hormones
a. Prolactin
b. TSH
c. GH (produced by somatotrophs)
d. ACTH
C. GH
o **TSH is the least abundant
- Adult growth hormone deficiency is due to?
a. Idiopathic cause
b. Pituitary adenoma
c. Body mass index
d. All of these
B. Pituitary adenoma
o **Among children the most common cause is Idiopathic
- The cell of the pituitary glands that secretes prolactin
a. Corticotroph – ACTH
b. Gonadotroph – FSH & LH
c. Lactotroph
d. Somatotroph – GH
C. Lactotroph
o Also known as Mammotroph
- It is also known as neurohypophysis
a. Anterior pituitary gland – Adenohypophysis
b. Adrenal gland
c. Posterior pituitary gland
d. Pituitary gland –Hypophysis
C. Posterior pituitary gland
