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hema two Flashcards

1
Q
  1. It measures the time required to generate thrombin and fibrin polymers via intrinsic pathway.
A

aTTP

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2
Q
  1. The following are negatively charge particulate activator used in aPTT reagent except?
A

Thrombin

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3
Q
  1. An increase in aPTT will affect the following coagulation factor except?
A

Factor VII

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4
Q
  1. The rate of Thrombin-Induced cleavage of fibrinogen to fibrin monomers and the subsequent polymerization of hydrogen bonded polymers?
A

Thrombin time

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5
Q
  1. It is also known as Plasma Thromboplastin Component or Christmas factor?
A

Factor IX

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6
Q
  1. The following coagulation factor are consumed during the process of coagulation except.
A

Factor XII

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7
Q
  1. Which of the following coagulation factor is inhibited by warfarin?
A

Factor IX

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8
Q
  1. The specimen of the patient with prolonged aPTT was subjected to mixing studies. After an immediate mixing, it normalizes and after 2 hour incubation period, still prolonged.
A

Factor VIII inhibitor

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9
Q
  1. This procedure is to monitor oral anticoagulant therapy, a screening test for diagnosis of coagulation deficiencies and a component of liver profile assessment
A

Prothrombin Time or PT

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10
Q
  1. It involves the principle of adding of plasma to an excess extrinsic thromboplastin calcium substrate.
A

Prothrombin Time or PT

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11
Q
  1. The following coagulation factor therefore being detected by this test except?
A

Factor IX

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12
Q
  1. Which of the following coagulation factor is not consumed during a process of coagulation?
A

Factor XI

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13
Q
  1. Which of the following coagulation factors will be most likely affected if the patient has Vitamin K deficiency?
A

Factor IX

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14
Q
  1. Anti-factor aPTT is usually associated with obviously with FVIII inhibitor that is the patient is usually associated with
A

Bleeding

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15
Q
  1. This test is used to identify and quantitate deficiencies in the intrinsic clotting system and to control anticoagulant therapy.
A

aPTT

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16
Q
  1. The following coagulation factor are consumed during the process of coagulation EXCEPT
A

Proconvertin or FVII

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17
Q
  1. The following are the Calcium and Vitamin K independent coagulation factors except.
A

PTC or Plasma Thromboplastic Component or FIX

18
Q
  1. The following are considered as serine proteases except
A

Labile or Factor V

19
Q
  1. Which of the following will serve as an activator in Prothrombin Time Test?
A

Neither

20
Q
  1. The following are calcium and vitamin K dependent coagulation factor except
A

Plasma Thromboplastin Antecedent of FIX

21
Q
  1. The component of aPTT reagent which will activate the contact factor in intrinsic pathway
A

PF3

22
Q
  1. Which of the following serves as a source of tissue factors
A

Both

23
Q
  1. The primary in vivo initiation mechanism for extrinsic coagulation cascade depends on the formation of
A

Complex of Tissue factor and FVII

24
Q
  1. When a person has Vitamin K deficiency, the following coagulation factor with most likely be affected except;
A

Factor V

25
Q
  1. It is considered as the marker of thrombosis and fibrinolysis
A

D-dimer or Fragment D&D

26
Q
  1. The component of aPTT reagent which is required to activate the prothrombin and the common pathway
A

Calcium chloride

27
Q
  1. A subtype of vWD characterized by mutation within the A1 structural domain of vWF molecule
A

Subtype 2B vWD

28
Q
  1. A subtype of vWD characterized by autosomal point mutation in the A2 and D1 structural domain of vWF molecule
A

Subtype 2A vWD

29
Q
  1. A subtype of vWD characterized by an autosomal vWF gene missense mutation in the D9 structural domain of of vWF molecule
A

Subtype 2N vWD or Normandy Variant

30
Q
  1. A subtype of vWD characterized by qualitative vWF variant that possesses poor platelet receptor binding site generating a normal multimeric distribution pattern in electrophoresis
A

Subtype 2M vWD

31
Q
  1. aPTT – PROLONGED PT- PROLONGED
    SOLUTION:
    PROBLEM: X,V,II,I
    Aged Serum (NC) – I, II, V, VIII, XIII
    Aged Plasma (NC) – V, VIII
    Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A

PROACCELLERIN (Letter E)

32
Q
  1. aPTT – PROLONGED PT- PROLONGED
    SOLUTION:
    PROBLEM: X,V,II,I
    Adsorbed Plasma (NC) – II,VII,IX,X
    Fresh Serum (C) – II, VII, IX, X, XI, XII
    Aged Serum (C) – VII, IX, X, XI, XII
A

STUART FACTOR

33
Q
  1. aPTT – PROLONGED PT- PROLONGED
    SOLUTION:
    PROBLEM: X,V,II,I
    Fresh Serum (NC) – I, V,VIII, XIII
    Aged Serum (NC) – I,II, V, VIII, XIII
    Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A

FIBRINOGEN

34
Q
  1. aPTT – PROLONGED PT- PROLONGED
    SOLUTION:
    PROBLEM: X,V,II,I
    Adsorbed Plasma (NC) – II,VII,IX,X
    Fresh Plasma (C) –I, II, V, X
    Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A

PROTHROMBIN

35
Q
  1. aPTT – PROLONGED PT- PROLONGED
    SOLUTION:
    PROBLEM: X,V,II,I
    Fresh Serum (C) – II, VII, IX, X, XI, XII
    Aged Serum (C) – VII, IX, X, XI, XII
    Aged Plasma (NC) – V, VIII
A

NO ANSWER
(Letter E)

36
Q
  1. aPTT – PROLONGED PT- NORMAL
    SOLUTION:
    PROBLEM: VIII, IX, XI, XII
    Aged Plasma (C) – I, II, VII, IX, X, XI, XII
    Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
    Aged Serum (C) – VII, IX, X, XI, XII
A

PLASMA THROMBOPLASTIN ANTECEDENT or HAGEMAN FACTOR
(Letter E, kasi dalwa sagot!!)

37
Q
  1. aPTT – PROLONGED PT- NORMAL
    SOLUTION:
    PROBLEM: VIII, IX, XI, XII
    Fresh Serum (NC) – I, V,VIII, XIII
    Aged Plasma (NC) – V, VIII
    Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A

ANTIHEMOPHLIC FACTOR A

38
Q
  1. aPTT – PROLONGED PT- NORMAL
    SOLUTION:
    PROBLEM: VIII, IX, XI, XII
    Adsorbed Plasma (NC) – II,VII,IX,X
    Fresh Serum (C) – II, VII, IX, X, XI, XII
    Aged Serum (C) – VII, IX, X, XI, XII
A

PLASMA THROMBOPLASTIN COMPONENT

39
Q
  1. aPTT – PROLONGED PT- NORMAL
    SOLUTION:
    PROBLEM: VIII, IX, XI, XII
    Aged Serum (NC) – I, II, V, VIII, XIII
    Fresh Plasma (C) –VIII, IX, XI, XIII
    Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A

ANTIHEMOPHLIC FACTOR A

40
Q
  1. aPTT – PROLONGED PT- NORMAL
    SOLUTION:
    PROBLEM: VIII, IX, XI, XII
    Adsorbed Plasma (NC) – II,VII,IX,X
    Aged Serum (C) – VII, IX, X, XI, XII
    Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A

CHRISTMAS FACTOR

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