hema two Flashcards
1
Q
- It measures the time required to generate thrombin and fibrin polymers via intrinsic pathway.
A
aTTP
2
Q
- The following are negatively charge particulate activator used in aPTT reagent except?
A
Thrombin
3
Q
- An increase in aPTT will affect the following coagulation factor except?
A
Factor VII
4
Q
- The rate of Thrombin-Induced cleavage of fibrinogen to fibrin monomers and the subsequent polymerization of hydrogen bonded polymers?
A
Thrombin time
5
Q
- It is also known as Plasma Thromboplastin Component or Christmas factor?
A
Factor IX
6
Q
- The following coagulation factor are consumed during the process of coagulation except.
A
Factor XII
7
Q
- Which of the following coagulation factor is inhibited by warfarin?
A
Factor IX
8
Q
- The specimen of the patient with prolonged aPTT was subjected to mixing studies. After an immediate mixing, it normalizes and after 2 hour incubation period, still prolonged.
A
Factor VIII inhibitor
9
Q
- This procedure is to monitor oral anticoagulant therapy, a screening test for diagnosis of coagulation deficiencies and a component of liver profile assessment
A
Prothrombin Time or PT
10
Q
- It involves the principle of adding of plasma to an excess extrinsic thromboplastin calcium substrate.
A
Prothrombin Time or PT
11
Q
- The following coagulation factor therefore being detected by this test except?
A
Factor IX
12
Q
- Which of the following coagulation factor is not consumed during a process of coagulation?
A
Factor XI
13
Q
- Which of the following coagulation factors will be most likely affected if the patient has Vitamin K deficiency?
A
Factor IX
14
Q
- Anti-factor aPTT is usually associated with obviously with FVIII inhibitor that is the patient is usually associated with
A
Bleeding
15
Q
- This test is used to identify and quantitate deficiencies in the intrinsic clotting system and to control anticoagulant therapy.
A
aPTT
16
Q
- The following coagulation factor are consumed during the process of coagulation EXCEPT
A
Proconvertin or FVII
17
Q
- The following are the Calcium and Vitamin K independent coagulation factors except.
A
PTC or Plasma Thromboplastic Component or FIX
18
Q
- The following are considered as serine proteases except
A
Labile or Factor V
19
Q
- Which of the following will serve as an activator in Prothrombin Time Test?
A
Neither
20
Q
- The following are calcium and vitamin K dependent coagulation factor except
A
Plasma Thromboplastin Antecedent of FIX
21
Q
- The component of aPTT reagent which will activate the contact factor in intrinsic pathway
A
PF3
22
Q
- Which of the following serves as a source of tissue factors
A
Both
23
Q
- The primary in vivo initiation mechanism for extrinsic coagulation cascade depends on the formation of
A
Complex of Tissue factor and FVII
24
Q
- When a person has Vitamin K deficiency, the following coagulation factor with most likely be affected except;
A
Factor V
25
Q
- It is considered as the marker of thrombosis and fibrinolysis
A
D-dimer or Fragment D&D
26
Q
- The component of aPTT reagent which is required to activate the prothrombin and the common pathway
A
Calcium chloride
27
Q
- A subtype of vWD characterized by mutation within the A1 structural domain of vWF molecule
A
Subtype 2B vWD
28
Q
- A subtype of vWD characterized by autosomal point mutation in the A2 and D1 structural domain of vWF molecule
A
Subtype 2A vWD
29
Q
- A subtype of vWD characterized by an autosomal vWF gene missense mutation in the D9 structural domain of of vWF molecule
A
Subtype 2N vWD or Normandy Variant
30
Q
- A subtype of vWD characterized by qualitative vWF variant that possesses poor platelet receptor binding site generating a normal multimeric distribution pattern in electrophoresis
A
Subtype 2M vWD
31
Q
- aPTT – PROLONGED PT- PROLONGED
SOLUTION:
PROBLEM: X,V,II,I
Aged Serum (NC) – I, II, V, VIII, XIII
Aged Plasma (NC) – V, VIII
Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A
PROACCELLERIN (Letter E)
32
Q
- aPTT – PROLONGED PT- PROLONGED
SOLUTION:
PROBLEM: X,V,II,I
Adsorbed Plasma (NC) – II,VII,IX,X
Fresh Serum (C) – II, VII, IX, X, XI, XII
Aged Serum (C) – VII, IX, X, XI, XII
A
STUART FACTOR
33
Q
- aPTT – PROLONGED PT- PROLONGED
SOLUTION:
PROBLEM: X,V,II,I
Fresh Serum (NC) – I, V,VIII, XIII
Aged Serum (NC) – I,II, V, VIII, XIII
Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A
FIBRINOGEN
34
Q
- aPTT – PROLONGED PT- PROLONGED
SOLUTION:
PROBLEM: X,V,II,I
Adsorbed Plasma (NC) – II,VII,IX,X
Fresh Plasma (C) –I, II, V, X
Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A
PROTHROMBIN
35
Q
- aPTT – PROLONGED PT- PROLONGED
SOLUTION:
PROBLEM: X,V,II,I
Fresh Serum (C) – II, VII, IX, X, XI, XII
Aged Serum (C) – VII, IX, X, XI, XII
Aged Plasma (NC) – V, VIII
A
NO ANSWER
(Letter E)
36
Q
- aPTT – PROLONGED PT- NORMAL
SOLUTION:
PROBLEM: VIII, IX, XI, XII
Aged Plasma (C) – I, II, VII, IX, X, XI, XII
Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
Aged Serum (C) – VII, IX, X, XI, XII
A
PLASMA THROMBOPLASTIN ANTECEDENT or HAGEMAN FACTOR
(Letter E, kasi dalwa sagot!!)
37
Q
- aPTT – PROLONGED PT- NORMAL
SOLUTION:
PROBLEM: VIII, IX, XI, XII
Fresh Serum (NC) – I, V,VIII, XIII
Aged Plasma (NC) – V, VIII
Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A
ANTIHEMOPHLIC FACTOR A
38
Q
- aPTT – PROLONGED PT- NORMAL
SOLUTION:
PROBLEM: VIII, IX, XI, XII
Adsorbed Plasma (NC) – II,VII,IX,X
Fresh Serum (C) – II, VII, IX, X, XI, XII
Aged Serum (C) – VII, IX, X, XI, XII
A
PLASMA THROMBOPLASTIN COMPONENT
39
Q
- aPTT – PROLONGED PT- NORMAL
SOLUTION:
PROBLEM: VIII, IX, XI, XII
Aged Serum (NC) – I, II, V, VIII, XIII
Fresh Plasma (C) –VIII, IX, XI, XIII
Adsorbed Plasma (C) – I,V, VIII, XI, XII, XIII
A
ANTIHEMOPHLIC FACTOR A
40
Q
- aPTT – PROLONGED PT- NORMAL
SOLUTION:
PROBLEM: VIII, IX, XI, XII
Adsorbed Plasma (NC) – II,VII,IX,X
Aged Serum (C) – VII, IX, X, XI, XII
Aged Plasma (C) – I, II, VII, IX, X, XI, XII
A
CHRISTMAS FACTOR
