hema one Flashcards
- Anemia can be caused by chronic blood loss or acute blood loss
both
- A Classification of anemia, or MCV, is > 90 fl but MCHC is normal
Macrocytic normochromic anemia
- Impaired release of storage iron associated with increased HEPCIDIN LEVEL
Anemia of chronic disease
- Caused by block in the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload
Sideroblastic anemia
- Anemia with normocytic normochromic anemia, by characteristics cause of basophilic stippling
Seen in lead poisoning
- A falsely elevated hematocrit is obtained, which of the following calculated values will not be affected.
MCH
- Which of these types of anemia are under the category of impaired production
Iron deficiency, sideroblastic anemia, anemia of chronic inflammations. All of the choices are types of anemia are impaired types of anemia
- The RBC indices obtained in the patient are as follows:
MCV: 88 fl
MCH: 30 pg
MCHC: 34%
Rbc on the pbs would appear:
Normocytic normochromic anemia
- (DATA TABLE) in an uncomplicated cases of severe iron deficiency anemia which of the following sets shows typical pattern of results
Decrease rbc, hemoglobin, mcv, mch, mchc, serum iron, serum ferritin, percent saturation, bone marrow iron stores, RDW distribution width and TIBC and serum soluble transferrin receptors are increased
- What is the first type of cell that is produced by the developing embryo
Erythrocytes
- As most blood cells lines matures, which of the following is the characteristics
Nucleus to cytoplasm ratio decreases N:C decrease
- DAT is open positive
Acquired hemolytic anemia
- Anemia of chronic infection is characterized by:
Decrease Serum iron levels
- A patient is admitted with a history of chronic bleeding secondary to peptic ulcer, hematology workup reveals severe microcytic hypochromic anemia. Iron studies are requested: which of the following will be expected
Decrease serum iron, increase TIBC, decrease storage iron
- Which of the set of laboratory findings is consistent with hemolytic anemia
Decrease in erythrocyte survival, increase of catabolism of protein content of heme
- Chronic blood loss can lead to
Gradual loss of blood, Lead to loss of iron leading to iron deficiency anemia
- Many microspherocytes, schistocytes, budding off of spherocytes can be seen in PBS with:
Extensive burns
- A beta lipoproteinemia is characterized by malt anemia and numerous
Acanthocytes in PBS
- Most common cause of iron deficiency
Bleeding
- Ineffective erythropoiesis is due to the following except:
Iron deficiency anemia
- These red blood cell parameter is increased in iron deficiency anemia.
TIBC
- If there is defective glucose 6 phosphate dehydrogenase in red cells. The cause of hemolysis is:
Hemolysis of intrinsic
- In chronic posthemorrhagic anemia, which is not true
Reticulocyte count is very low
- Isoimmune hemolytic disease of the newborn is
Due to ABO incompatibility
- In aplastic anemias the marrow cellularity is usually
Decreased
- Rh null disease person shows morphological changes in red cell while person with rh negative conditions possess CDE antigens
The first statement is true, second statement is false
- Acanthocytes and echinocytes can be differentiated based on the following:
All of the above
- The opposite of aplastic anemia (no or few production)
Polycythemia
- Extrinsic hemolytic anemia is caused by:
All of the choices
Due to physical agents, Hidden trauma, vegetable animal poison, infectious agents like malarial parasites and bacteria
- Defect of rbc itself usually hereditary are grouped and group as membrane, metabolic or hemoglobin defects
Intrinsic hemolytic anemia
- Anemia most commonly present in which of the following symptoms
Shortness of breath and fatigue Note: Because of the lack of oxygen supply
- Which of the following conditions can be differential diagnosis of anemic adult patient with
MCV of 125 fl
RDW: 20 %
Reference is 11.5-14.5%
Vit.b12 deficiency
- Schistocytes, ovalocytes, acanthocytes are example of abnormal changes in:
Shape
- Which of the following is detectable only in the examination of PBS.
poikilocytosis
- Which of the following conditions are considered anemic with hemoglobin value of 14.5 g/dl
Newborn
- What are the initial lab test for diagnosis of anemia:
CBC, reticulocyte count, PBS
- An increase in which of the following suggest a shortened lifespan of rbc in hemolytic anemia
Increase of reticulocyte, Reticulocyte count
- An autoimmune reaction destroys hematopoietic stem cells in the bone marrow of a young adult patient. Amount of active bone marrow including erythroid precursors is diminished. Erythroid precursors that are present are normal in appearance but are too few to meet the demand of circulating red cells and anemia develops, reticulocyte count is low. the mechanism of anemia would be described as:
Insufficient erythropoiesis
- Which of the following are important to consider a patient’s history when investigating the cause of anemia
All of the above
Diet and medication, occupation hobbies and travel, bleeding episodes in his/her family members, genetics
- To determine which of the following conditions would be included in the differential diagnosis of anemic adult patient with absolute reticulocyte count of 20x10^9/L MCV of 65fl
Iron deficiency anemia
