SM02 Mini1 Flashcards
approximately how many people are killed by NCDs worldwide per year?
35 million or 2/3 of all death
what percentage of NCD deaths occur in low & middle income countries?
80%
How much do NCDs usually cost the US per year?
billions
4 behavioral risk factors for NCDs
- poor diet
- little to no exercise/physical inactivity
- smoking
- alcohol/drug abuse
4 biological risk factors for NCDs
- raised BP (HTN)
- raised blood sugar (diabetes)
- raised cholesterol
- raised BMI (obesity &/or overweight)
what are the top to leading causes of death in the US over the last 75 years?
heart dz & cancer, respectively
What is a positive trend seen in heart dz in the last decade?
downward trend in percentage of adults w/at least one of three risk factor (uncontrolled HTN, uncontrolled LDL, or smoking)
primordial prevention
create framework or environment for prevention of production or exposure to risk factor
target: reduce initial exposure
ex. age legislation on purchase of cigarettes or banning of smoking in ppublic
primary prevention
removal of risk factor or increasing resistance before dz process begins
target: asymptomatic persons to prevent dz (exposed but not diseased- ex. second hand smoker)
ex. smoking cessation programs/respirators for silica
secondary preventation
detection of asymptomatic dz
target: those early in dz process to prevent progression to symptomatic stages
seeks to improve prognosis
ex. screening programs
tertiary prevention
management or rehabilition of established dz
targets: those w/established dz to halt/retard dz progression & limit complication and/or disability OR to rehabilitate those w/functional and/or socla disabilites
ex. tx of COPD pts/drug abusers
screening
presumptive identification of unrecognized dz or defect by application of tests, examinations or other procedures that can be applied rapidly
form of secondary prevention
validity measured by sensitivity & specificity
sensitivity
ability of screening test to identify person who have dz
sensitivity= (pts w/dz who tested +)/(all pts w/dz)= a/(a+c)
specificity
ability of screening test to identify persons who do not have dz
specificity= (tested -)/(true- + false+)= d/(b+d)
positive predictive value
probability that pt w/+ test result is true + for dz
PPV= (pts w/dz who tested +)/(all pts who tested +)= a/(a+b)
negative predictive value
probability that pt w/- test result is true - for dz
PPV= (pts w/o dz who tested -)/(all pts who tested -)= d/(c+d)
prevalence
measure of dz frequency
proportion of persons in defined population that has the outcome of interest at a defined instant in time
includes old & new cases
incidence
measure of dz frequency of NEW cases
risk, odds, or rate
Risk
measure of incidence
probability of occurrence of an outcome in an outcome-free population during a specified time period
risk= (#of new cases)/(population initially at risk)= d/N
usually applied to non-recurrent dz or first episode
Odds
total # of new cases divided by total # of person who remained dz-free over study period
Odds= d/(N-d)
ratio of probability of getting dz to probability of not getting dz in a given time period
Rate
express # of people w/condition or #of events in relation to total population at risk
rate= (# ppl w/condition)/(#total pop. at risk) for given time frame
age-specific rate
numerator & denominator refer to same specific age group
crude rates
rates calculated on total numbers of persons
NOT specific for age, ethnicity, socioeconomic class, etc. (risk factors)
case fatality rate
proportion of case of a specified cause which dies in a specified period of time
usually expressed as a percentage
cause specific mortality rate
of death by specific cause in defined pop./ unit population in defined period of time