slide flashcards W2D4
autoreceptor function
feed back mechanism on presynaptic neuron which can tell neuron to stop releasing neurotransmitters “youve done enough”
what are the canabenoid receptors
CB1 and CB2
what binds to canabenoid receptors (besides weed)
anandemide and 2AG
how many subunits in an ionotropic receptor
4-5
how many subunits in a metabotropic receptor
one
what type of receptor has an ion channel and which type of receptor do ions not pass through
ionotropic = ion channel
betabotropic = metabolic cascade
what is special about NMDH receptors
coincidence receptor.
blocked by magnesium and needs depolarization + ligand to bind to alosteric site to activate
what are side effects (of drugs) from
non-selective drugs (bind to all subtypes of target as opposed to specific subtype)
explain the process of a metabotropic receptor
neurotransmitter binds to receptor (first messenger), g protein switches GDP to GTP and activates effector enzyme (adenyly cyclase) aka the second messenger
what is the effector enzyme that produces cAMP then protein kinase A
adenylyl cyclase
name 3 serotonin receptors
5HT1 (inhibitory autoreceptors), 5HT2 (hallucinagenic, lsd is agonist), 5HT3 (ionotropic, excitatory like nicotinic ACh receptors)
what are the two important norepinephrine receptors and are the inhibitory or excitatory
beta = excitatory
alpha2 = inhibitory
are dopamine receptors metabotropic or ionotropic or both
all metabotropic, no ionotropic
are norepinephrine receptors metabotropic, ionotropic, or both
all metabotropic, no ionotropic (like dopamine)
name 3 glutamate receptors
NMDA, AMPA, kainate
what kind or receptor is/what do we know about NMDA receptors
ionotropic, ‘coincidence receptor’, excitatory
what neurotransmitter uses adenylyl cyclase to make cAMP
glutamate
what kind or receptor is/what do we know about AMPA receptors
sionotropic, excitatory, provide the depolarization for the ‘kicking out’ of magnesium in NMDA receptors
what kind or receptor is/what do we know about kainate receptors
ionotropic, excitatory
are glutamate receptors ionotropic, metabotropic, or both
all (that we talk about at least) are ionotropic
name the gaba receptor
GABAa
what do we know about GABAa receptors
ionotropic, sensitive to alcohol, benzos etc
drug action (def)
how a protein changes in response to a drug
drug effect (def)
how the drug effects your physiology
inverse agonist (def)
ligand that makes activity of a receptor absolute zero (even with antagonists there is some base level of activity)
types of agonists
full agonist, partial agonist, inverse agonist
antagonist (def)
binds to receptor and blocks receptor activity
indirect/alosteric/noncompetitive binding (def)
seperate binding sites for neurotransmitter and other ligand(s)
direct/competitive binding (def)
one binding site for ligand and neurotransmitter
