slide flashcards W2D4

Question 1

autoreceptor function

Answer 1

feed back mechanism on presynaptic neuron which can tell neuron to stop releasing neurotransmitters “youve done enough”

Question 2

what are the canabenoid receptors

Answer 2

CB1 and CB2

Question 3

what binds to canabenoid receptors (besides weed)

Answer 3

anandemide and 2AG

Question 4

how many subunits in an ionotropic receptor

Answer 4

4-5

Question 5

how many subunits in a metabotropic receptor

Answer 5

one

Question 6

what type of receptor has an ion channel and which type of receptor do ions not pass through

Answer 6

ionotropic = ion channel
betabotropic = metabolic cascade

Question 7

what is special about NMDH receptors

Answer 7

coincidence receptor.

blocked by magnesium and needs depolarization + ligand to bind to alosteric site to activate

Question 8

what are side effects (of drugs) from

Answer 8

non-selective drugs (bind to all subtypes of target as opposed to specific subtype)

Question 9

explain the process of a metabotropic receptor

Answer 9

neurotransmitter binds to receptor (first messenger), g protein switches GDP to GTP and activates effector enzyme (adenyly cyclase) aka the second messenger

Question 10

what is the effector enzyme that produces cAMP then protein kinase A

Answer 10

adenylyl cyclase

Question 11

name 3 serotonin receptors

Answer 11

5HT1 (inhibitory autoreceptors), 5HT2 (hallucinagenic, lsd is agonist), 5HT3 (ionotropic, excitatory like nicotinic ACh receptors)

Question 12

what are the two important norepinephrine receptors and are the inhibitory or excitatory

Answer 12

beta = excitatory
alpha2 = inhibitory

Question 12

are dopamine receptors metabotropic or ionotropic or both

Answer 12

all metabotropic, no ionotropic

Question 12

are norepinephrine receptors metabotropic, ionotropic, or both

Answer 12

all metabotropic, no ionotropic (like dopamine)

Question 13

name 3 glutamate receptors

Answer 13

NMDA, AMPA, kainate

Question 14

what kind or receptor is/what do we know about NMDA receptors

Answer 14

ionotropic, ‘coincidence receptor’, excitatory

Question 15

what neurotransmitter uses adenylyl cyclase to make cAMP

Answer 15

glutamate

Question 16

what kind or receptor is/what do we know about AMPA receptors

Answer 16

sionotropic, excitatory, provide the depolarization for the ‘kicking out’ of magnesium in NMDA receptors

Question 17

what kind or receptor is/what do we know about kainate receptors

Answer 17

ionotropic, excitatory

Question 18

are glutamate receptors ionotropic, metabotropic, or both

Answer 18

all (that we talk about at least) are ionotropic

Question 19

name the gaba receptor

Answer 19

GABAa

Question 20

what do we know about GABAa receptors

Answer 20

ionotropic, sensitive to alcohol, benzos etc

Question 21

drug action (def)

Answer 21

how a protein changes in response to a drug

Question 22

drug effect (def)

Answer 22

how the drug effects your physiology

Question 23

inverse agonist (def)

Answer 23

ligand that makes activity of a receptor absolute zero (even with antagonists there is some base level of activity)

Question 24

types of agonists

Answer 24

full agonist, partial agonist, inverse agonist

Question 25

antagonist (def)

Answer 25

binds to receptor and blocks receptor activity

Question 26

indirect/alosteric/noncompetitive binding (def)

Answer 26

seperate binding sites for neurotransmitter and other ligand(s)

Question 27

direct/competitive binding (def)

Answer 27

one binding site for ligand and neurotransmitter