slide flashcards W1D1

1
Q

taratogen (def)

A

environmental factors (toxins, viruses, etc) that disrupt embryonic or fetal development

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2
Q

trisomy (def)

A

3 copies of a chromosome (down syndrome is example of non-lethal trisomy)

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3
Q

what is a baby called from weeks 3-8

A

embryo

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4
Q

during what period is a baby an embryo

A

weeks 3-8

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5
Q

what is a baby called from weeks 9-40

A

fetus

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6
Q

when is a baby called a fetus

A

weeks 9-40

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7
Q

what is the phase called before a baby is an embryo

A

preimplantation phase

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8
Q

how many days post conception does gastrolation occur

A

13-19 days post conception

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9
Q

what is invagination

A

the formation of the primitive streak along midline (during gastrolation)

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10
Q

in a blastocyst, what are the two components

A

epiblast and hypoblast (fluid filled cavity)

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11
Q

what is the trophoblast and what does it become

A

cells forming edge of blastula/blastocyst that becomes the placenta

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12
Q

what is a notochord

A

rod-like structure that defines the midline of the embryo and the position of CNS also sends signals to the ectoderm above to differentiate into the neural plate

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13
Q

the ectoderm thickens and grows into the BLANK over the BLANK

A

the ectoderm thickens and grows in the NEURAL PLATE over the NOTOCHORD

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14
Q

the cell devides from the midline (what stucture is there)

A

primitive streak notochord determins midline

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15
Q

cells continue deviding some faster than others forming the BLANK

A

neural groove

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16
Q

ridges of the neural ggroove join forming the BLANK which eventualy becomes the BLANK

A

ridges of the neural groove join forming the NEURAL TUBE wich eventually becomes the CNS

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17
Q

ectoderm columns are pinched off from each side of the neural tube (the sides of the neural tube are called the BLANK) which become BLANK and BLANK

A

ectoderm columns are pinched off from each side of the neural tube (called the NEURAL CREST) which eventually become sensory and autonomic ganglia (PNS)

18
Q

what is the neural crest

A

ectoderm cells next to neural groove that are pinched off and become sensory and autonomic ganglia (PNS)

19
Q

what does the notochord become in adult humans

A

nucleous pulposes in spine

20
Q

what happens during prenatal developement if there is excessive vitamin a

A

can impede neural tube closer and differentiation

21
Q

what are the meninges

A

protective membrains covering + surrounding brain

22
Q

name the three meninges from out to in

A

dura matter, arachnoid matter, pia matter

23
Q

through which layer of meninges do blood vessels flow

A

arachnoid matter/space

24
Q

stem cell definition

A

a single cell that can either 1. replicate itself or 2. differentiate into many different cell types

25
Q

what are the two zones during neurogenesis

A

ventricular and marginal zone

26
Q

cells in the ventricular zone during neurogenesis will BLANK

A

continue to devide/devide again

27
Q

cells in the marginal zone during neurogenesis will BLANK

A

eventually leave the ventricular zone and will differentiate into either neurons or glial cells

28
Q

how do cells know where to go in brain + how do they get there

A

migrating cells ‘climb’ along radial glia and move away from ventricular layer, the migrating cells release molecules that guide other cells

29
Q

what are radial glia cells

A

Cells. That. aid in cell migration (migrating cells ‘climb’ the radial glia)

30
Q

where do radial glia cells come from

A

neuroepithelial cells

31
Q

are radial glia cells precurser neurons

A

yes, radial glia are a type of precurser neuron cell and produce neuroblasts and glioblasts

32
Q

what is lissencephaly

A

brain with no folds

33
Q

the fate of a differentiating cell depends on both BLANK and BLANK

A

the fate of a differentiating cell depends on both its GENETIC PROGRAM and CHEMICAL SIGNALS it receives from its surroundings

34
Q

gene expression is effected by BLANK to BLANK interactions

A

CELL to CELL interactions

35
Q

what is process outgrowth

A

the extensive growth of young axons and dendrites

36
Q

how do axons know where to point/go

A

guided by attracting chemical signals released by target cells

37
Q

extensions at the tips of axons and dendrites are called BLANK

A

growth cones

38
Q

why does neuronal cell death ocur

A

competition for synaptic sites, size of the target area, competition for chemicals (food), neurotropic factors

39
Q

what makes neurotropic factors

A

target cells

40
Q

what is a neurotropic factor

A

protien produced by target cell(s) which regulate expression of genes and affect development of the neuron

41
Q

what 2 things influence synaptic survival/not dying

A

neural activity (use or lack of use) and neurotrophic factors

42
Q

what does enrichment/an enriched environment effect (4)?

A
  • more glial cells per neuron
  • thicker cerebral cortex
  • increased dendritic complexity
  • increased synaptic efficacy