slide flashcards W2D2
what is dale’s law
that each neuron specializes and synthesizes only one neuron (WRONG)
what does it mean if a neuron is serotogenic
produces serotonin, does NOT mean that it has serotonin receptors or only responds to serotonin
what does it mean if a neuron is dopamegenic
produces dopamine, does NOT mean that it has dopamine receptors or only responds to dopamine
true or false: neurotransmitters are taken up by receptors/receiving neuron
FALSO
what protiens bring vesicles carying neurotransmitters to cell membrain to be released into synapse
snare protiens
what is clathrin and what does it do
protien that reuptakes/recycles vesicles (similar to transporter protiens and neurotransmitters)
ligand (def)
something that binds to a receptor
exogenous (def)
made outside of the body (foreign)
endogenous (def)
made inside the body
name the catecholamines
dopamine, epinephrine, norepinephrine
name the indoleamine(s)
serotonin
name the imidazoleamine(s)
histamine
name the amino acid neurotransmitters
glutamate, aspartate, GABA, glycine
name the peptide neurotransmitters
opiodes, vasopressin, oxytocin
name 3 atypical neurotransmitters
anandamide, nitric acid, carbon monoxide
what causes a neuron to release peptides in addition to neurotransmitters
HIGH firing rate (this is REALLY important info)
name the neuromodulators
acetylcholine, dopamine, serotonin
process of acetylcholine synthesis + degradation
choline + acetylCoA——–ChaT enzyme——–acetylcholine——-AChE enzyme—-choline + acetyleCoA
order of catecholamine synthesis
tyrosine—–TH enzyme——-L-dopa——enzyme—–dopamine—-enzyme—-norepinephrine——enzyme—–epinephrine
what does dopamine ‘deal with’
reward, working memory/planning, motor innitiation + termination
what does norepinephrine ‘deal with’
allertness, mood, sympathetic activation
what does epinephrine ‘deal with’
mood, agression, obsessive/compulsive behaviors, anxiety, sleep, pain
name the 3 dopamine pathways
nigrostriatal, mesolimbic, and mesocortical pathways
the BLANK (movement) pathway sends dopamine to BLANK and is associated with BLANK disease
nigrostriatal pathway sens dopamine to the midbrain and is associated with parkinsons disease
the BLANK (drug reward) pathway sends dopamine to BLANK and is associated with BLANK SYMPTOMS of BLANK disease
the mesolimbic pathway sends dopamine to forebrain and is associated with positive symptoms of skitzofrenia
the BLANK (executive functioning) pathway sends dopamine to BLANK and is associated with BLANK SYMPTOMS of BLANK disease
the mesocortical pathway sends dopamine to prefrontal cortex and is associated with negative symptoms of skitzophrenia
where is the substantia nigra
midbrain, above crus cerebri
which dopamine pathway(s) starts at the substantia nigra and where does it go
the nigrostriatal pathway starts at the substantia nigra and sends dopamine to the midbrain
which dopamine pathway(s) starts at the ventral tegmental area and where does it go
the mesolimbic and mesocortical pathways start at the ventral tegmental area/midline/midbrain and send dopamine to the forebrain and prefrontal cortex respectivly