sleep Flashcards
narcolepsy
daytime sleepiness
cataplexy
hypnagogic hallucinations
sleep paralysis
dysfunctional hypocretin peptide pathway
at least 3x per week for 3 mo
MDD polysomnography
prolonged sleep latency
increased wake time after sleep onset
increased early morning awakenings
decreased total sleep time
decreased slow wave sleep
dec slow wave sleep as percentage of total sleep time
reduced REM latency= quickened approach to REM
prolongation of first REM sleep period
increased REM activity
increased REM sleep percentage
modafinil
hypocretin/orexin pathway
OSA adjunct
how CPAP works
air flowing through mask pneumatically splints airway open, providing constant positive pressure to airway muscles and preventing them from collapsing
lesions to this cause fluctuations in mood
anterior and medial thalamus
length of time for hypersomnolence DO criteria to be met
3 mo
kleine Levin syndrome
epsiodes lasting days to weeks of
hypersomnia
hyperphagia
cognitive dysfunction
newborn sleep
sleep longer but in short intervals
go to REM at sleep onset
have increased RED sleep time with decreased NREM sleep time
at 3 mo old, start to enter NREM at sleep onset and develop circadian phases
hypnotics half life
zaleplon: 1-2 hrs
zolpidem, triazolam: 2-3 hrs
eszopiclone: 6 hrs
temazepam: 10-20 hours
DSM5 parasomnias
non REM sleep arousal disorders (sleepwalking and sleep terrors)
nightamare DO
REM sleep behavior DO
restless legs syndrome
where melatonin is made
serotonin derivative made in pineal gland
% of kids with sleepwalking DOs
10-30%
% of people with narcolepsy have catplexy
60%
how modafinil promotes wakefulness
demonstrates histaminergic mechanism in addition to increasing dopamine by binding to dopamine transporter
tuberomammillary nucleus, the stiatum, the cingulate cortex and higher doses
