SLE/scleroderma Flashcards
CT diseases are associated with
ANA
SLE
- Inflammatory autoimmune disorder that may affect multiple organ systems
- hyperactive immune response
hallmark of SLE
- ANA
- Trapping of antigen-antibody complexes in capillaries of visceral structures causing inflammation & blood vessel abnormalities.
serious complications of SLE?
- nephritis leading to renal failure
- CNS
MCC drug induced SLE
- Procainamide
- hydralazine
- INH
chronic, scarring, atrophy producing, photosensitive dermatosis.
Discoid lupus erythematosus (DLE)
what is typically the first manifestation of SLE?
- arthritis of small joints and wrists
- nonerosive and nondeforming
4 or more are req for a SLE dx
Malar rash Discoid rash Photosensitivity Oral ulcers Arthritis Serositis Renal disease- i.e.proteinuria, casts Neurologic- i.e. seizures, psychosis Hematologic disorders- hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia Immunologic abnormalities-anti-dsDNA \+ANA (1:40 or higher) not related to severity of disease
this correlates with disease severity
complement (C3 and C4)
SLE tx
NSAIDs Low dose steroids (prednisone) Hydroxychloroquine Immunosuppressants-Methotrexate Cyclophosphamide (lupus nephritis)
scleroderma
excessive collagen deposited around capillaries, small vessels and in affected tissues, such as the skin, lungs, kidneys, and esophagus
limited scleroderma is characterized by
Calcinosis
Raynaud’s (MC presenting sign white/blue/red)
Esophagela dysfunction
Sclerodactyly
Telangiectasias
involves face and distal limbs, not trunk
diffuse scleroderma
extensive skin thickening proximal to the elbows and knees along with internal organ involvement
common pulm problem relating to scleroderm
Alveolitis leading to pulmonary fibrosis is a common complication of scleroderma
treat sclerodermal renal crisis with
ACE I
