Gout and Pseudogout Flashcards
1
Q
gout has these crystals
pseudogout has these
A
monosodium urate monohydrate calcium pyrophosphate (CPP)
2
Q
gout is a common inflammatory disease caused by
A
hyperuricemia
3
Q
MCC etiology of hyperuricemia is
A
underexcretion
decreased renal clearance
4
Q
purines are degraded into urates in the
A
liver and small intestine
5
Q
common presenting complaints of gout
A
- acute monoarticular arthritis
- Podagra (inflammation of the first metatarsophalangeal joint)
6
Q
tophi
A
- collection of urate crystals
- commonly in the helix of the ear
7
Q
what is the definitive dx of gout?
A
- aspiration
- needle shaped, negative bi-fringent
- make sure to r/o septic joint
8
Q
how to treat an acute attack of gout?
A
- indomethacin (NSAID)
- corticosteroids if they can’t take NSAIDs
- colchicine is given regardless (also for prophylaxis)
9
Q
ho to manage chronic gout?
A
- allopurinol (blocks xanthine oxidase)
- probenecid
10
Q
pseudogout
A
- MC > 60
- MC affects knees, wrists, hips
- polyarticular
11
Q
4 Hs of psuedogout
A
Hemochromatosis
Hyperparathyroidism
Hypophosphatasia
Hypomagnesemia
12
Q
are lab studies useful for pseudogout?
A
NO
13
Q
what is seen when examining pseudogout materials?
A
- rhomboid shaped, positive bifringence
- chondrocalcinosis
14
Q
how to treat pseudogout
A
- steroids
- NSAIDs
- colchicine
