SkM Relaxant Pharmacology Flashcards
Which drugs are NDNM blocking drugs (Isoquinolines)
Atracurim Cisatracurium Doxacurium Mivacurium Metocurine Tubocurarine
Which drugs are NDNM blocking drugs (Steroids)
Pancuronium
Pipercuronium
Rocuronium
Vecuronium
Which drugs are charged AchEi’s
Ambenonium Echothiphate Edrophonium Neostigmine Pyridostigmine
Which drugs are uncharged AchEi’s
Donepezil Galantamine Physostigmine Rivastigmine Tacrine
Which drug is the DNM blocking drug
Succinylcholine
MOA: Atropine
mAchR antagonist/inhibitor –> decreased PNS activity
MOA: Pralidoxime
AchE regenerator –> decreased PNS activity
Which drugs are centrally acting spasmolytics
Baclofen Carisprodol Cyclobenazprine Diazepam Tizanidine
Which drugs are non-centrally acting spasmolytics
Dantrolene
Botulinum toxin
Which drugs are used to Tx MS
Glatiramer acetate
IFN-ß-1a/b
Mitoxantrone
Major SE’s: Atracurium
Less histamine release
Major SE’s: Cisatracurium
Safe w/ renal/hepatic impairment
Major SE’s: Doxacurium
Not used in pts w/ renal failure
Major SE’s: Mivacurium
Histamin release, CV effects
Major SE’s: Succinylcholine
Combo w/ volatile anesthetics –> Malignant hyperthermia
Major SE’s: Ambenonium
Causes decreased activity of NDNM blocking agents
Enhances bradycardia of ß-blockers
Why is the Echothiphate different from the other drugs in its class
Only AchEi requiring Pralidoxime for reversal of its effects
Which centrally acting spasmolytic also has anti-anxiety effects
Carisprodol
Which non-centrally acting spasmolytic can cause hepatitis
Dantrolene
Which centrally acting spasmolytics are schedule IV substances
Carisprodol
Diazepam
