Pathology - Bone/Soft Tissue Tumors Flashcards
Def: malignant cartilage tumor in the medulla of the pelvis or central skeleton in > 40 yo m
Chondrosarcoma
Def: mass extending from metaphysis of bone w/ cartilage cap
Osteochondroma
Def: tumor of osteoblasts > 2cm w/ bone pain that doesn’t get better w/ aspirin/NSAIDs
Osteoblastoma
Sx’s: Onion-skin on X-ray
Ewing Sarcoma
Def: benign tumor of osteoblasts in males < 25 yo in the cortex of long bones
Osteoid Osteoma
Def: benign tumor on facial bones assc w/ Gardner syndrome
Osteoma
Sx’s: painful enlarging mass in the pelvis or central skeleton
Chondrosarcoma
Mutation assc w/ Chondroma
IDH1
Hist: locally aggressive tumor that may recur
Giant cell tumor
The cartilage in an Osteochondram can transform to…
Chondrosarcoma
Def: Osteolytic (punched-out) lesions in bone
Metastatic tumors
What is the MC 1˚ malignant bone tumor
Osteosarcoma
What determines the prognosis of Chondrosarcoma
Grade
Osteoblastic lesions are created by mets from what tumor
Prostatic carcinoma
Sx’s: painful bony mass (< 2cm) that gets better w/ aspirin/NSAIDs
Osteoid Osteoma
Ollier syndrome =
Chondroma w/ multiple lesions
Mutations assc w/ teenage Osteosarcoma…
Rb TP53 INK4A MDM2/CDK4 HER2
Hist: small, round blue cells (Homer-Wright rosettes) w/ scant cytoplasm
Ewing Sarcoma
Def: malignant proliferation of osteoblasts in teenagers in the metaphysis of long bones
Osteosarcoma
What commonly precedes Osteiod Osteomas
Sinus infection
Mutation assc w/ Ewing Sarcoma
t(11;22) EWSR1-FLI1
Maffucci variety =
Chondroma w/ increased risk of sarcoma
Def: cartilage tumor arising in the medulla of small bones of the hands and feet
Chondroma
Def: tumor of multinucleated giant cells and stromal cells in young adults in the epiphysis of long bones that makes “soap-bubble” appearance on X-ray
Giant cell tumor
