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Zak, MSK 2 > Analgesic Pharmacology > Flashcards

Analgesic Pharmacology Flashcards

1
Q

MOA: Aspirin

A

Irreversible COX1/2 inhibition

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2
Q

MOA: Celecoxib

A

Inhibits COX2 –> decreased inflammation, pain, fever

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3
Q

MOA: Tramadol

A

µ agonist blocking NE and 5-HT reuptake

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4
Q

MOA: Ketamine

A

NDMA-antagonist creating trance-like state

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5
Q

MOA: Dexmedetomidine

A

a2-adrenergic agonist causing sedation

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6
Q

MOA: Clonidine

A

a2-adrenergic agonist blocking pain signals from periphery to CNS

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7
Q

MOA: Ziconotide

A

N-type voltage sensitive Ca-channel antagonist on afferent neurons in dorsal horn of spinal cord preventing pain signal from periphery to CNS

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8
Q

Clinical application: Tramadol

A

Moderate/Severe pain

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9
Q

Clinical application: Ketamine

A

Anesthesia/Post-op

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10
Q

Clinical application: Dexmedetomidine

A

Analgesia, sedation

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11
Q

Clinical application: Clonidine

A

Severe pain

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12
Q

Clinical application: Ziconotie

A

Chronic severe pain

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Zak, MSK 2 (17 decks)

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