Pathology - Inflammatory Dermatoses Flashcards
Hist: Parakeratosis (creates silver scale), Munro microabscesses (neutrophils in S. Corneum), and thinning of the epidermis above elongated dermal papillae
Psoriasis
Auspitz sign
Bleeding when a silver scale is removed from a psoriatic patch
What is the pathogen assc w/ Acne Vulgaris
Propionibacterium acnes
Hist: DE junction inflammation w/ “saw-tooth” appearance
Lichen Planus
Def: Type 1 HSTY RXN assc w/ asthma and allergic rhinitis
Atopic Dermatitis (Eczema)
What are the layers of the epidermis from deep to superficial
Basalis Spinosum Granulosum Corneum
What is the Tx for Psoriasis
Corticosteroids UV light w/ Psoralen Immune-modulating therapy
What is the etiology of Acne Vulgaris
Hormone-assc increase in sebum production and excess keratin production forming comedones
Sx’s: pruritic, erythematous, oozing rash on face and extensor surfaces
Atopic Dermatitis (Eczema)
Def: Chronic autoimmune disease w/ excessive keratinocyte proliferation creating epidermal hyperplasia
Psoriasis
Psoriasis is assc w/ which HLA
HLA-C
Def: Chronic inflammation of hair follicles and assc sebaceous glands
Acne Vulgaris
What is the Tx of Acne Vulgaris
Benzoyl Peroxide Vitamin A (Isoretinoin)
Def: pruritic, erythematous, oozing rash d/t exposure to allergens
Contact Dermatitis
What is the Tx for Contact Dermatitis
Removal of offending agent Topical Glucocorticoids
What are the Sx’s of Lichen Planus
Pruritic Planar Polygonal Purple Papules (Wickham Striae)
Where does Lichen Planus typically occur
Wrist Elbows Oral mucosa
Lichen Planus is assc w/…
Chronic HSV
Sx’s: salmon-colored plaques w/ silvery scale on extensor surfaces, scalp, and pitting of nails
Psoriasis
