Skin pathology Flashcards
where are melanocytes found
dermo epidermal junction
basal layer
what is the epidermis mainly of
maturing squamous cells
normal epidermis
stratified keratinising squamous epithelium
what is the granular layer rich in
keratohyalin granules
layers of epidermis
Prickle cells-prominent desmosomes
Granular layer-rich in keratohyalin granules
Corneal layer-differentiated keratinised cells
Corneocytes-shed from surface-house dust
how do melanocytes transfer pigment
to keratinocytes. via dendritic processes
where are langerhans cells located
upper and mid epidermis
what collagen is in the dermis
type 1 and 3 collagen
what does the reticular dermis contain
appendage structures- sweat glnds, pilosebaceous units
papillary v reticular dermis
thin v thick
papillary is just below epidermis
reticular is just below papillary
parakeratosis
persistence of nuclei in the keratin layer
acanthosis
increased thickness of epithelium
hyperkeratosis
increased thickness of keratin layer
papillomatosis
irregular epithelial thickening
spongiosis
oedema between cells of epidermis
can cause skin to appear red, swollen and can lead to formation of blisters
spngiotic
epidermal oedema - eczema
psoriasiform
elongatikon of rede edges
lichenoid
basal layer damage - lichen planus and lupus
vesiculobullous
blistering e.g pemphigoid
lichenoid disorders
conditons characterisd by damage to asal epidermis
vesicobullous blistering examples
pemhigoid, pemhigus and dermatitis herpetiformis
