Immunology and bio them

Question 1

langerhan cells

Answer 1

antigen presenting cell that intersperse with keratinocytes in epidermis

specialised dendritc cell

Question 1

what are langerhan cells characterised by

Answer 1

birbecl granule- tennis racquet

Question 2

what layer are cd8+t cells mainly found

Answer 2

epidermis

Question 3

what are foound in the dermis

Answer 3

cd4+ and cd8+ t cells

Question 4

TH1 inflammation assoc

Answer 4

psoriasis

Question 5

th2 inflammation assoc

Answer 5

atopic dermatitis

Question 6

th17 inflammation assoc

Answer 6

psoriasis and atopic dermatitis

Question 7

condition where nuetrophils dont work

Answer 7

chronic granulomatous disease

Question 8

inflammatory diseases where macrophages are too active

Answer 8

rosacea , RA

Question 9

conditions where macrophages are too lame

Answer 9

reduced control of tumour- tumour assoc macrophages

Question 10

what have been found at high levels in the skin of patients with psoriasis

Answer 10

high level of AMPS

Question 11

function of keratinocytes

Answer 11

• Sense a pathogen via cell surface receptors and help mediate an (innate) immune response

Produce antimicrobial peptides (AMPs) that can directly kill pathogens

produce cytokines and chemokines

Question 12

main skin resident immune cell

Answer 12

langerhans

Question 13

where are t cells found

Answer 13

in epidermis and dermins

Question 14

immune cells of dermis

Answer 14

dermal dc - antigen presenting

plasmacytoid dc ; produce ifn alpha found in diseased skin