Random Flashcards
underlying cause of pemphigus
antibodies to desmogleins
underlying process of pemphigoid
antibodies to hemidesmosomes
desmogleins
adhesion molecule between epithelial cells in the skin
igg deposition between cells in epidermis
pemphigus
chicken wire appearance
pemphigus
igg antibodies to basement membrane
pemphigoid
negative nikolsky sign
pemphigoid
which diseases show koebners phenom
psoriasis
vitilgio
lichen planus
first line in acne
topical retinoid adn topic antibiotic
what is not recommended in acne
corticosteroids
hemidesmosomes proteins in pemphigoid
bp180 and bp230
investigatin for contact dermatitis
patch test
first line managemrnt for dh
dapsone
acne first line treatment
Topical Benzoyl Peroxide and Adapalene combination
side effect of isotretinoin
skin fragility
what is nail pitting assoc with
psoriais
exzema
alopecia
5 ps for lichen planus
Purple
Pruritic
Papular
Polygonal
Planar (flat topped)
ladder of meds for acne
topical treatments, abx, retinoida
withdrawl of steroids is a recognised trigger of what
psoriaiss
classification for ceullulitis
eron clasification
Class 1 (systemically well, no comorbidities), Class 2 (systemically unwell/poorly controlled comorbidities), Class 3 (SIRS/very poorly controlled comorbidities), Class 4 (septic shock/life-threatening infection).
treatment for pregnant owman with cellulitis
erythromycin.
what is tractin alopecia due to
hairstyles
alopecia
localised non scarring alopecia
whole scalp alopecia name
sotalis allopecia
trichotillomania causes
self induced pcikign hair out
where is tinea captis seen in
areas of poverty
what is tinea captis
fungal infection on scalp
what is kerion
immune repsonse to fungal infecion on scalp
severe
lanugo hair type
fine long hairs covering the foetus
shed about one month before birth
vellus hair type
fin eshort hair covering much of body surfaces
replaces lanugo hairs before birth
terminal hair type
long coarse hairs e.g scalp
growth influenced by androgen levels
autoimmune cause of hair loss
alopecia areata
first line t5reatment for alopecia areata
potent or super potent topical corticosteroid - clobetasol, dermovate
drugs linked to bullous pemphigoid
Spironolactone, Furosemide, Sulfasalazine, Penicillins, Beta-blockers, Antipsychotics and Enoxaparin.
first line treatment for rosacea
ivermectin
scaly plaques
squamous cell
visible telangiectasia
basal cell carcinoma
what setting does a marjolin ulcer occur in
squamous cell carcinoma in the history or traumatised skin
type of melanoma on shins
superficial spreading
melanoma on nail bed
subungal
melanoma on palms, soles and nail beds
acral lenitngiuso
melanoma most commonly found on trunk and most aggressive
nodular
melanoma most common in elderly due to orolonged sun exposure
lentigo
biggest risk factor for developing bcc
immunosuppression
bresllow thickness
from granular layer to deepest invafding cell
what does phaemelanin cause
red hair
what does MC1R dtermine
balance of pigment in skin and hair
what does one defective copy of mc1r cause
freckkles
what does two defective copies in mc1r gene cause
red hair and freckles
fitzpatrick skin phototypes
I Only burns
II Burns, can tan
III Tans, can burn
IV Tans
V Dark brown skin
VI Black skin
what does the spf factor relate to
how effectively they block UVB
UVA v UVB
UVB is. ashort wavelenght only reaching in summer months
UVA longer wavelength
what uv do we have most exposure to
UVA
what is a photon of UVR absorbed by
dna in nucleus of keratinocyte
which uv is more dangerous a or b
b
what ahppens to p53 with more sun damage
mutant p53 clones increase in number and size
what do keratinocytes secrete
il-10 and other immunosuppressive molecules
polymorphic light eruption
reaction rash to the sunn
what is xeroderma pigmentosum charaterised by
severe photosensitivity, skin pigmentary changes, malignant tumor development,
complication of eczema
eczema hyperticum usually due to herpes
clusters of red blisters
itchy and painful
management of eczema hyperticum
usually hopsital admission
target antigens in pemphigus
desmogleins 1 and 3
when to apply emollient in eczema
post shower
fusidic acid use
impetigo
what is eczema herpeticum treated with
intravenous aciclovir as it is an antiviral
treatment for urticaria
non-sedating antihistamines such as Cetirizine/Loratidine/Fexofenadine
where do venous ulcers present
gaiter area - lowr leg
where do arterial ulcers present
foot
normal a bpi
between 1 and 1.4
streptococaanl infection involing epidermis making brihgt red on face and puffy
erysipleas
3 month old - fever, irritability, extensive blistering around mouth, armpit groin
Staphylococcal scalded skin syndrome
example of a retinoid
oral isotretinoin
second line for severe acne
2 antibiotics then a retinoid
what alopecia is stress an important factor in
areata
abnormal skin sensations and pain, followed by a unilateral vesicular rash in the affected dermatome
shingles
treatment for bowens
imiquimoid
MOA of clopidogrel
antagonist against adp receptor
what is used to monitor unfractioned heparin
aptt
what is dermatoscopy
exammination of the skin using a camera like tool
what are patients with scleoris at risk of developig
pulmonary hypertension
known porphyrinogenic
trimethoprim
drugs involved in plaque psoriasis
beta blcokers
