Skin Manifestations of Systemic Dz Flashcards
Pyoderma Gengrenosum
Rapidly evolving, idiopathic chronic and severely debilitating ulcerative skin dz.
Associated with chronic dz
Pyoderma Gangrenosum is associated with?
Chronic ulcerative colitis ** Chronic active hepatitis RA Crohns Hematologic malignancies
Pyoderma Gengrenosum S/S
Acute onset painful hemorrhagic pustule or painful nodule surrounded by erythematous halo.
Lower extremities, buttocks, abdomen.
Pyoderma Gengrenosum Tx
Treat underlying dz
Avoid trauma
Hugh-dose systemic steroids
Immunosuppression
Acanthosis Nigricans
Velvety thickening and hyperpigmentation of skin.
Seen in Diabetes, obesity, GI malignancy
Necrobiosis Lipoidicia (NL)
Unknown origin
50% of patients are diabetics
Oval, violaceous patch that expands slowly
Advancing border is red, central area turns yellow
NL Tx
Refer to derm
Granuloma Annular
Self-limiting, asymptomatic, chronic dermatosis.
Association w/ diabetes.
Insidious onset
Dorsum of hands and feet, extremities and trunk.
Intertrigo
irritation of skin folds Worse w/ heat and moisture Diabetes, HIV, obesity Related to candida Keep cool and dry, antifungals
Heliotrope eyelid rash, Gottrons papules
Dermatomyositis
Xanthomas
Lipid deposits in skin and tendons. Upper and lower eyelids, inner canthus.
Hyperlipidemia, Biliary cirrhosis, diabetes, CRF
If Xanthelasma is seen in children or young adults….
It is associated with familial hypercholesterolemia
Erythema multiforme
Multiple morphologic presentations
Can be due to many medications
Can involve mucous membranes
Can be associated with hepatitis, nephritis
SJS, TEN
Mucotaneous drug-induced or idiopathic rxn characterized by skin tenderness and erythema of skin mucosa, followed bu extensive necrosis and sloughing.
SJS, TEN onset
1-3 weeks post-drug exposure
Most common >40 yo
SLE, HIV, HLA-B12
