Skin Immunology

Question 1

4 factors contributing to skin as an immunological system

Answer 1

structure (keratin layer, stratification)

cell types (immune cells, keratinocytes)

chemical signals/ molecules - cytokines, chemokines eicosanoids, antimicrobial peptides (influence behaviour)

Genetics

Question 2

in immunodeficient, what immune response can occur

Answer 2

infection not controlled, tumours may form

Question 3

autoimmunity immune response would be a reaction to

Answer 3

host tissue leading to chronic inflam

Question 4

describe the keratin layer

Answer 4

tough lipid rich, acts as physical barrier

Question 5

what are the structural and functional cells of epidermis

Answer 5

keratinocytes

Question 6

2 things which activate keratinocytes

Answer 6

UV

allergic contact

Question 7

3 things produced by keratinocytes

Answer 7

AMPs
Cytokines
Chemokines

Question 8

Langerhans cells are

Answer 8

antigen presenting cells, contain birbeck granule

Question 9

t/f langerhans activate t cells

Answer 9

true

present to effector T cels

Question 10

which type of t cell is most prominent in skin

Answer 10

CD8+

Question 11

where are CD4+ and Cd8+ found in skin

Answer 11

dermis

Question 12

CD4+ TH cells associated with inflammation include TH1, leading to

Answer 12

Psoriasis

Question 13

atopic dermatitis is due to which immune cell

Answer 13

CD4+ Th2

Question 14

2 types of dendritic cells found in dermis

Answer 14

dermal DC (ag presentation, secreting cyto/chemokines)
plasmacytoid DC (in disease)

Question 15

other than dendritic cells, 3 types in dermis

Answer 15

macrophages
neutrophils
mast cells

Question 16

examples of cells with MHC II

Answer 16

B cells

macrophages

Question 17

what pathological function causes psoriasis

Answer 17

chronic inflammation

Question 18

impairment of skin barrier function is a key factor for atopic eczema, 2 components of this are

Answer 18

mutations in fillagrin

reduced AMP in skin

Question 19

t/f t cells, DC,KC, macrophages and mast cellsa re found in lesions

Answer 19

true

Question 20

defective skin barrier allows sensitisation to _____ and ______ _____ by micro-organisms

Answer 20

allergen
promotes
colonisation

Question 21

3 structural proteins in keratin layer

Answer 21

filaggrin
involucrin
keratin

Question 22

another name of keratin layer

Answer 22

stratum corneum

Question 23

psycosocial stress is the most important factor for (2)

Answer 23

eczema

psoriasis