9 - allergy and skin

Question 1

define type 1 allergy

Answer 1

immediate reaction (mins up to 2hrs post exposure) 
consistent reaction with every exposure

Question 2

most common presentation

Answer 2

uticaria
angioedema
wheezing/asthma
anaphylaxis

Question 3

investigations for allergy

Answer 3

history
bloods- specific IgE
skin prick test
challenge test
serum mast cell tryptase level (during anaphylaxis)

Question 4

allergy management

Answer 4

avoidance
anti-histamines - mast cell inhibition 
anti-inflammatory - corticosteroids
adrenaline autoinjector (anaphylaxis) epipen
mast cell stabilisers (Na Cromo) 
immunotherapy (only useful for some)

Question 5

dose for epipen for children/adults

Answer 5

150 micro g

300 micro g

Question 6

uticaria can occur due to direct mast cell degranulation, which drugs can cause this

Answer 6

morhpine
aspirin
NSAIDS

Question 7

define type 4 allergy

Answer 7

delayed hypersensitivity
antigen specific, T cell mediated
allergic contact dermatitis, occurring 24-48hrs post exposure