10 - pharmacology

Question 1

what is the outermost layer of the skin

Answer 1

stratum corneum

Question 2

what holds the layer of skins together (the corneocytes)

Answer 2

intercellular lipids

Question 3

choice of vehicle used to administer is dictated by 2

Answer 3

physiochemical properties of the drug

clinical condition

Question 4

conventional transdermal drug delivery is a passive process, driven by

Answer 4

diffusion

Question 5

2 factors affecting drug absorption

Answer 5

permeability

concentration of drug (J=Kp x Cv)

Question 6

factors contributign to permeability (Kp)

Answer 6

drug
barrier
partition coefficient (Km), diffusion coefficient (D), length of diffusion pathway (L)

Kp = DKm/L

Question 7

as drug is dissolved, what happens to its conc in vehicle

Answer 7

remains unchanged

Question 8

factors influencing absorption of topical drugs

Answer 8

nature of skin

• site of application = thickness
• hydration
• integrity of epidermis (hairy,moist/dry)

drug prep

• drug conc
• drug salt
• vehicle

Question 9

if skin is moist, which type of vehicle

Answer 9

powder

Question 10

permeability of areas ranked from hardness to softest

Answer 10

nail
palm/sole
trunk
face/scalp
scrotum