Skin Immunology

Question 1

How do keratinocytes defend against pathogens? (2)

Answer 1

1. produce anti-microbial peptides that can directly kill pathogens
2. produce cytokines and chemokines which recruit the adaptive and innate immune system

Question 2

What type of cell are langerhans cells?

Answer 2

dendritic cells

Question 3

How do the langerhans cells act as the skins immune system?

Answer 3

act as an APC taking Ag and microbial fragments to the lymph nodes and activating T cells

Question 4

T cells found in the epidermis

Answer 4

predominantly CD8+

Question 5

T cells found in the dermis

Answer 5

CD8+ and CD4+

Question 6

Th cells associated with inflammation include (3)

Answer 6

Th1, Th2 and Th17

Question 7

Th cells associated with psoriasis

Answer 7

Th1 and Th17

Question 8

Th cells associated with atopic dermatitis

Answer 8

Th2 and Th17

Question 9

Cells acting as part of the immune system in the dermis

Answer 9

Dendritic cells, Macrophages, Neutrophils, Mast cells

Question 10

Pre-formed mediators released by mast cells

Answer 10

histamine, tryptase, chymase and TNF

Question 11

newly synthesised mediators released by mast cells

Answer 11

IL, TNF, Leukotrienes, PGE

Question 12

Chromosome for MHC

Answer 12

Chromosome 6

Question 13

MHC Class I features (3)

Answer 13

1. found on almost all cells 2. present Ag to cytotoxic T cells 3. present endogenous Ag

Question 14

MHC Class II features (3)

Answer 14

1. found on APC (B cells, macrophages) 2. present to Th cells 3. present exogenous Ag