Skin immunology

Question 1

Keratinocytes

Answer 1

Structural and functional cells of the epidermis

Helps to mediate an immune response as it senses pathogens via cell surface receptors (AMPs)

Question 2

What are keratinocytes activated by?

Answer 2

UV (sunlight)

Sensitisers - which cause allergic contact dermatitis

Question 3

Type of T cell in the epidermis

Answer 3

Mainly CD8+ T cell

Question 4

Types of T cell in the dermis

Answer 4

CD4+ and CD8+ T cell

Question 5

CD4+ Helper T cells (Th1)

Answer 5

Intracellular

Activate macrophages to destroy micro-organisms through release of IL2 and IFN-gamma

Question 6

CD4+ Helper T cells (Th2)

Answer 6

Extracellular

Help B cells make antibody through release of IL4, IL5, IL6

Question 7

Inflammation associated TH cells

Answer 7

TH1, TH2, TH17

Question 8

CD8+ cytotoxic T cells

Answer 8

Can kill cells directly

Question 9

Dendritic cells present in the dermis

Answer 9

Dermal DC
- involved in antigen presentation. secrete chemo/cytokines

Plasmacytoid DC
- produce IFN-alpha. Found in diseased skin

Question 10

Neutrophils are found in the epidermis/dermis

Answer 10

Dermis

Question 11

Macrophages are found in the epidermis/dermis

Answer 11

Dermis

Question 12

Mast cells are found in the epidermis/dermis

Answer 12

Dermis

Question 13

Primary immunodeficiency

Answer 13

Inherited directly

Question 14

Secondary immunodeficiency

Answer 14

Acquired in life time

Question 15

What is an immunodeficiency?

Answer 15

Results from an inadequate immune response

Question 16

Non immune cells in the epidermis

Answer 16

Keratinocytes

Question 17

Immune cells in the epidermis

Answer 17

Langerhans cells and T cells

Question 18

Immune cells in the dermis

Answer 18

Dendritic cells, macrophages, Neutrophils, Mast cells