Skin Cancer Flashcards
SCC mortality vs BCC
higher in SCC- more likely to mets
cell origin of SCC
keratinocyte, usually mutated by UV mutations via p53
morpho of SCC
papule, plaque or nodule
scale, exophytic, indurated w/ thick, firm feeling
friable, usually asx
what is bowens disease
SCC in situ, keratinocyte atypia confined to epidermis and does not invade dermal epidermal junction
becomes SCC invasive after entering dermis
tx for SCC
excision, curette and desiccation for in situ
radiation or 5 fluorouracin cream
rate of metastasis for SCC
if on sun exposed skin, 5% to go to regional nodes
Actinic keratosis
premalignant
gritty erythematous macules or thin plaques
higher suspicion of SCC if hthick or tender
progression to invasive SCC
sun damaged skin
actinic keratosis
SCC in situ
invasive SCC
features of sun damaged skin
combo of atrophy and hypertrophy
telangectasias, spotty depigmentation, wrinkles, leathery
actinic purpura
easy bruising in elderly
actinic cheilosis
AKs on lips, usually lower
patch w/ rough gritty scale- persistent ulcerations or indentions should be biopsied
AK tx
localized- cryotherapy
field- topical 5FU or imiquimod creams, phototherapy
most common skin cancer
BCC
cell origin and etiology of BCC
keratinocyte
PTCH tumor suppressor mutation, from UV DNA damage
most common BCC subtyp
nodular- pearly papule or nodule w/ rolled border and telangectasias
usually head and neck
