Acne

Question 1

acne vulgaris is a disorder of

Answer 1

pilosebaceous follicles

Question 2

3 classifications of acne

Answer 2

comedonal- open and closed comedones

inflammatory- papules and pustules

nodulocystic- nodules and cysts

need to note severity of scarring

Question 3

4 pathogenic factors

Answer 3

hormones- androgens

sebaceous gland activity

plugging of hair follicles from abnormal keratinization

P acnes bacteria in hair follicle living in lipids and causing inflammation

Question 4

tx for acne, mild to sever

Answer 4

mild comedonal- topical retinoid

mild pap/putular- topical clinda or eryhtromycin

mod pap/pustular or mild nodular- oral antibiotics

severe scarring or nodular- isotretinoin

Question 5

topical retinoids

Answer 5

vit A derivatives

can cause dryness, rednes, photosensitivity

Question 6

3 types of topical antibiotics

Answer 6

erythromycin, clindamycin

benzoyl peroxide

takes 4-6 weeks to work

Question 7

oral antibiotics for inflammatory acne

Answer 7

mino and doxycycline

Question 8

side effects of oral antibiotics

Answer 8

mino- vertigo, vestibular toxiic

doxy- highly photosenstizing

GI upset

dont affect OCP

Question 9

indication for oral isotretinoin

Answer 9

severe, nodulocystic, recalcitrant acne- low threshold w/ scarring

Question 10

side effects of isotretnoin

Answer 10

chapped lips, dry skin, cheilitis, elevated LFTs, hyperTGs, psuedotumor cerebri

highly teratogenic