Cutaneous Manifestations of Systemic Disease Flashcards
cutaneous findings of AL amyloidosis
macroglossia (can lead to tongue trauma), pinch purpura, waxy thickening, nodules/ plaques in periorbital region
dx of AL amyloid
biopsy needed- apple green on congro red in papillary dermis
serum and urine electrophoresis can detect light chains
tx of amyloid
treat plasma cell dyscrasia
main systems affected by sacroid
lungs and skin, but can be any system
mostly AA and female
biopsy of sarcoid
non caseating granulomas
skin finding of sarcoid
symmetric red brown papules/ plaques
logfrens syndrome
sarcoid w/ erythema nodosum, hilar adenopathy, fever
better px
what lesion has predilection of scars and and tatoos
sarcoid
tx for sarcoid
should remit, no cure
CS, antimalarials, minocycline, immunomodulators help
describe necrobiosis lipoidica, tx
necrotiing skin w/ DM
primarily young and middle aged adults
topical steroids firts line
skin findings of necrobiosis lipoidica
yellow brown atrophic telangiectatic plaques w/ elevated rim,
usually pretibial, flame like appearance
sweets syndrome epi
aka acute febrile neutrophilic dermatosis
usually female, 30-60, acute onset
clin pres of sweet syndrome
fever, malaise, abrupt erythematous palques w/ some vesiculation (usualy on head and neck but can be anywhere)
elevated WBC and pmn count
etiology of sweets
half idiopathic, half trigger
URIs like strep, malignancy (AML), chronic inflammatory
tx of sweets
tx underlying infection, systemic CS causes rapid improvement
