Skin and Systematic Disease

Question 1

what are cutaneous manifestations of underlying disease?

Answer 1

Malignant disease
GI and endocrine disease
Autoimmune conditions/ Connective tissue disease including vasculitis

Question 2

what are skin signs of GI haemorrhage?

Answer 2

Hereditary haemorrhagic telangiectasia

Blue rubber bleb naevus

Question 3

what are skin signs of IBD?

Answer 3

Erythema nodosum

Pyoderma gangrenosum

Question 4

what are skin signs of vitamin deficiency?

Answer 4

Scurvy / Beriberi

Question 5

what are some skin signs of diabetes?

Answer 5

Acanthosis nigricans
Diabetic bullae
Diabetic dermopathy
Eruptive xanthomas
Necrobiosis lipoidica

Question 6

what are some skin signs of hyperthyroid?

Answer 6

thyroid acropachy

Question 7

what are some skin signs of hypothyroid

Answer 7

Pre-tibial Myxoedema

Question 8

what are some autoimmunity skin diseases

Answer 8

Cutaneous lupus
Cutaneous vasculitis
Alopecia
Vitiligo

Question 9

what are the different types of presentation for cutaneous lupus?

Answer 9

butterfly rash
plaques with clear margins
photosensitivity
negative antibodies

Question 10

what is alopecia aerata?

Answer 10

common autoimmune skin disease, causing hair loss on the scalp, face and sometimes on other areas of the body

Question 11

what is the mechanism behind alopecia?

Answer 11

T-lymphocyte, cytokine rejection of hair

Totalis
Universalis

Question 12

what is the differential diagnosis of alopecia?

Answer 12

Scarring alopecia

Androgenic alopecia

Question 13

what is vitiligo?

Answer 13

Destruction of melanocytes

Question 14

what are the causes of underlying malignancy?

Answer 14

Carcinoid Syndrome
Ectopic ACTH
Pagets disease
Paraneoplastic pemphigus
Acquired hypertrichosis
Erythema Gyratum Repens
Bazex Syndrome
Leser Trelat

Question 15

what are the symptoms of carcinoid syndrome?

Answer 15

Episodic flushing, mins -hours
No sweating (unlike menopause)

Question 16

what is Facial telangiectasia

Answer 16

small, broken, or widened blood vessels

Question 17

what is the cause of GI carcinoid?

Answer 17

liver mets

Question 18

what does the tumour production of ACTH cause?

Answer 18

to generalised hyperpigmentation

Question 19

what are symptoms of pagets disease?

Answer 19

Eczematous Plaque (nipple/Areola)

• Extension of underlying ductal

Question 20

what are the symptoms of paraneoplastic pemphigus?

Answer 20

Erosive stomatitis, rash

Question 21

what triggers Paraneoplastic Pemphigus

Answer 21

Auto-antibodies driven

Question 22

what is Acquired hypertrichosis lanuginosa

Answer 22

Acute onset of lanugo hairs at face & body

Question 23

what is erythema gyratum repens associated with?

Answer 23

Concentric erythematous lesions

Associated with Lung ca > Oesophageal,Breast

Question 24

what is bazex syndrome?

Answer 24

Symmetrical hyperkeratosis of extremities – Acrokeratosis neoplastica
Resembles psoriasis, non-specific fx on skin biopsy
SCC: Bronchial, oropharyngeal, Gastric, colon, biliary adenocarcinomas

Question 25

what is leser-trelat?

Answer 25

Eruptive seborrhoeic keratosis

GI adenocarcinomas

Question 26

what are conditions associated with cancer?

Answer 26

Acanthosis Nigricans

Dermatomyositis

Question 27

what are symptoms and signs of dermatomyositis?

Answer 27

Inflammatory myopathy + rash
Periorbital heliotrope rash
Gottrons papules: red maculo-papular lesions over bony prominences
Shawl sign
Photosensitive 
Asso with -Ovarian, breast, lung ca

Question 28

what conditions may be associated with malignancy?

Answer 28

Bullous pemphgoid
Sweets Syndrome
Pyoderma gangrenosum
Acquired ichthyosis
Cryoglobulinaemia

Question 29

what are some examples of eponymous syndromes?

Answer 29

Peutz-Jeghers 
Muir-Torre
Neurofibromatosis
MEN syndromes
Howel-Evans